en
Scientific article
Open access
English

Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis

Published inNeuron, vol. 42, no. 6, p. 983-991
Publication date2004-06-24
Abstract

Neuroanatomical and electrophysiological studies have shown that hypothalamic POMC neurons are targets of the adipostatic hormone leptin. However, the physiological relevance of leptin signaling in these neurons has not yet been directly tested. Here, using the Cre/loxP system, we critically test the functional importance of leptin action on POMC neurons by deleting leptin receptors specifically from these cells in mice. Mice lacking leptin signaling in POMC neurons are mildly obese, hyperleptinemic, and have altered expression of hypothalamic neuropeptides. In summary, leptin receptors on POMC neurons are required but not solely responsible for leptin's regulation of body weight homeostasis.

eng
Keywords
  • Age Factors
  • Animals
  • Body Composition / genetics
  • Body Weight / physiology
  • Eating / genetics
  • Female
  • Gene Expression / genetics
  • Green Fluorescent Proteins
  • Homeostasis / physiology
  • Hypothalamus / cytology
  • Hypothalamus / metabolism
  • Immunohistochemistry / methods
  • In Situ Hybridization / methods
  • Leptin / blood
  • Leptin / pharmacology
  • Luminescent Proteins / metabolism
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Neurons / metabolism
  • Neuropeptides / metabolism
  • Oxygen Consumption / genetics
  • Pro-Opiomelanocortin / genetics
  • Pro-Opiomelanocortin / metabolism
  • RNA, Messenger / metabolism
  • Receptors, Cell Surface / physiology
  • Receptors, Leptin
  • Repressor Proteins / metabolism
  • Reverse Transcriptase Polymerase Chain Reaction / methods
  • Sex Factors
  • Signal Transduction / physiology
  • Suppressor of Cytokine Signaling 3 Protein
  • Suppressor of Cytokine Signaling Proteins
  • Transcription Factors / metabolism
  • Alpha-MSH / metabolism
Affiliation Not a UNIGE publication
Citation (ISO format)
BALTHASAR, Nina et al. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. In: Neuron, 2004, vol. 42, n° 6, p. 983–991. doi: 10.1016/j.neuron.2004.06.004
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0896-6273
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8downloads

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