Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis
ContributorsDhillon, Harveen; Zigman, Jeffrey M; Ye, Chianping; Lee, Charlotte E; McGovern, Robert A; Tang, Vinsee; Kenny, Christopher D; Christiansen, Lauryn M; White, Ryan D; Edelstein, Elisabeth A; Coppari, Roberto; Balthasar, Nina; Cowley, Michael A; Chua, Streamson (Jr); Elmquist, Joel K; Lowell, Bradford B
Published inNeuron, vol. 49, no. 2, p. 191-203
Publication date2006-01-19
Abstract
Keywords
- Adipose Tissue / drug effects
- Adipose Tissue / physiology
- Animals
- Body Composition / drug effects
- Body Composition / genetics
- Body Composition / physiology
- Body Weight / physiology
- Diet
- Electrophysiology
- Energy Metabolism / drug effects
- Energy Metabolism / genetics
- Energy Metabolism / physiology
- Green Fluorescent Proteins / metabolism
- Homeodomain Proteins / genetics
- Homeodomain Proteins / physiology
- Homeostasis / drug effects
- Homeostasis / physiology
- Immunohistochemistry
- In Vitro Techniques
- Leptin / pharmacology
- Male
- Mice
- Mice, Transgenic
- Neurons / drug effects
- Obesity / physiopathology
- Patch-Clamp Techniques
- Phenotype
- RNA Probes
- Receptors, Cell Surface / genetics
- Receptors, Cell Surface / physiology
- Receptors, Cytoplasmic and Nuclear / genetics
- Receptors, Cytoplasmic and Nuclear / physiology
- Receptors, Leptin
- STAT3 Transcription Factor / metabolism
- Signal Transduction / drug effects
- Signal Transduction / physiology
- Steroidogenic Factor 1
- Transcription Factors / genetics
- Transcription Factors / physiology
- Ventromedial Hypothalamic Nucleus / cytology
- Ventromedial Hypothalamic Nucleus / drug effects
Affiliation entities Not a UNIGE publication
Research groups
Citation (ISO format)
DHILLON, Harveen et al. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. In: Neuron, 2006, vol. 49, n° 2, p. 191–203. doi: 10.1016/j.neuron.2005.12.021
Main files (1)
Article (Published version)
Identifiers
- PID : unige:171539
- DOI : 10.1016/j.neuron.2005.12.021
- PMID : 16423694
Journal ISSN0896-6273