Article scientifique

Cefuroxime prophylaxis is effective in noninstrumented spine surgery: a double-blind, placebo-controlled study

Publié dansSpine, vol. 33, no. 18, p. 1919-1924
Date de publication2008

STUDY DESIGN: Double-blind, placebo-controlled randomized clinical trial. OBJECTIVE: To assess the efficacy of 1 preoperative 1.5 g dose of cefuroxime in preventing surgical site infection after surgery for herniated disc. SUMMARY OF BACKGROUND DATA: Antibiotic prophylaxis was only tested in nonconclusive trials in this setting. METHODS: The study was conducted in 2 university hospitals in Switzerland. Patients were assessed for occurrence of surgical site infection (defined by the criteria of the Centers for Diseases Control and Prevention), other infections, or adverse events up to 6 months after surgery. Outcome measures were compared in a univariate, per-protocol analysis. RESULTS: Baseline characteristics were similar in patients allocated to cefuroxime (n = 613) or placebo (n = 624). Eight (1.3%) patients in the cefuroxime group and 18 patients (2.8%) in the placebo group developed a surgical site infection (P = 0.073). A diagnosis of spondylodiscitis or epidural abscess was made in 9 patients in the placebo group, but none in the cefuroxime group (P < 0.01), which corresponded to a number necessary to treat of 69 patients to prevent one of these infections. There were no significant adverse events attributed to either cefuroxime or placebo. CONCLUSION: A single, preoperative dose of cefuroxime significantly reduces the risk of organ-space infection, most notably spondylodiscitis, after surgery for herniated disc.

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antibiotic Prophylaxis/methods
  • Cefuroxime/administration & dosage
  • Double-Blind Method
  • Female
  • Humans
  • Intervertebral Disk Displacement/drug therapy/surgery
  • Male
  • Middle Aged
  • Neurosurgical Procedures/adverse effects/methods
  • Surgical Wound Infection/prevention & control
Citation (format ISO)
PETIGNAT, Christiane et al. Cefuroxime prophylaxis is effective in noninstrumented spine surgery: a double-blind, placebo-controlled study. In: Spine, 2008, vol. 33, n° 18, p. 1919–1924. doi: 10.1097/BRS.0b013e31817d97cf
Fichiers principaux (1)
Article (Accepted version)
ISSN du journal0362-2436

Informations techniques

Création25/05/2009 16:14:00
Première validation25/05/2009 16:14:00
Heure de mise à jour14/03/2023 15:05:28
Changement de statut14/03/2023 15:05:28
Dernière indexation18/10/2023 10:27:54
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