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Doctoral thesis
English

Formulating equitable vaccines: investigating accessible adjuvants for pandemic prone diseases

ContributorsPeletta, Allegra
Number of pages188
Imprimatur date2023
Defense date2023
Abstract

Vaccination is considered one of the most successful strategies to prevent infectious diseases. In the event of a pandemic or epidemic, the rapid development and distribution of the vaccine to the population is essential to reduce mortality, morbidity, and transmission. As seen during the COVID-19 pandemic, the production and distribution of vaccines has been challenging, in particular for resource-constrained settings, essentially slowing down the process of achieving global coverage. Pricing, storage, transportation, and delivery requirements of several vaccines developed in high-income countries resulted in limited access for low-and-middle income countries (LMICs). The capacity to manufacture vaccines locally would greatly improve global vaccine access. In particular, for the development of classical subunit vaccines, the access to vaccine adjuvants is a pre-requisite for more equitable access to vaccines. Vaccine adjuvants are agents required to augment or potentiate, and possibly target the specific immune response to such type of vaccine antigens. Openly accessible or locally produced vaccine adjuvants may allow for faster immunization of the global population. For local research and development of adjuvanted vaccines to expand, knowledge on vaccine formulation is of paramount importance. In this review, we aim to discuss the optimal characteristics of a vaccine developed in an emergency setting by focusing on the importance of vaccine formulation, appropriate use of adjuvants and how this may help overcome barriers for vaccine development and production in LMICs, achieve improved vaccine regimens, delivery, and storage requirements.

eng
Keywords
  • Vaccines
  • Nucleic acid delivery
  • Drug delivery
  • Liposomes
  • Lipid nanoparticles
  • Dengue
  • Covid-19
  • Influenza
  • PLGA nanoparticles
  • Pandemics
  • Accessibility
  • Microfluidics
Research group
Citation (ISO format)
PELETTA, Allegra. Formulating equitable vaccines: investigating accessible adjuvants for pandemic prone diseases. 2023. doi: 10.13097/archive-ouverte/unige:170698
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Creation07/19/2023 2:37:13 AM
First validation08/16/2023 6:52:22 AM
Update time11/21/2023 11:32:58 AM
Status update11/21/2023 11:32:58 AM
Last indexation02/01/2024 10:32:01 AM
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