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English

HLA class II DRB1, DQA1 and DQB1 polymorphisms in the Polish population from Wielkopolska

Contributors

Jungerman, M; Sanchez-Mazas, Alicia; Fichna, P; Ivanova, R; Charron, D; Hors, J; Djoulah, S

Published in

Tissue antigens, vol. 49, no. 6, p. 624-628

Publication date

1997

Abstract

HLA DRB1, DQA1 and DQB1 alleles were determined by DNA PCR-SSO typing in a sample of 99 individuals originating from Wielkopolska (midwestern Poland). A high number of alleles (38 DRB1, 8 DQA1 and 14 DQB1) was detected at each locus, many of them presenting notable frequencies in this population. The three HLA loci are thus characterized by very high heterozygosity levels (93% for DRB1, 85% for DQA1, and 88% for DQB1), which confirms the results found for other European populations. A total of 6 DRB1-DQA1-DQB1 haplotypes are detected with an estimated frequency higher than 5%, namely, DRB1*1501-DQA1*0102-DQB1*0602, DRB1*0701-DQA1*0201-DQB1*0201, DRB1*0101-DQA1*0101-DQB1*0501, DRB1*1101-DQA1*0501-DQB1*0301, DRB1*03011-DQA1*0501-DQB1*0201, and DRB1*1301-DQA1*0103-DQB1*0603. A genetic distance analysis between the Polish and other world populations tested for HLA class II indicates that the Wielkopolska community is close to geographically close, rather than linguistically related populations from Europe. More generally, a good agreement between genetics and geography is found for DRB1 and DQB1 polymorphisms in Europe, suggesting that these two loci are highly informative for assessing historical relationships among humans.

Keywords

  • Alleles
  • Gene Frequency
  • HLA-DQ Antigens/genetics
  • HLA-DR Antigens/genetics
  • Haplotypes
  • Humans
  • Poland
  • Genetic Polymorphism

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

JUNGERMAN, M et al. HLA class II DRB1, DQA1 and DQB1 polymorphisms in the Polish population from Wielkopolska. In: Tissue antigens, 1997, vol. 49, n° 6, p. 624–628. doi: 10.1111/j.1399-0039.1997.tb02810.x

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

0001-2815
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Technical informations

Creation

09/09/2011 15:10:00

First validation

09/09/2011 15:10:00

Update

14/10/2025 00:31:07

Status update

14/03/2023 17:02:34

Last indexation

15/10/2026 22:58:41
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