UNIGE document Scientific Article
previous document  unige:17064  next document
add to browser collection

HLA class II DRB1, DQA1 and DQB1 polymorphisms in the Polish population from Wielkopolska

Jungerman, M
Fichna, P
Ivanova, R
Charron, D
Hors, J
Djoulah, S
Published in Tissue Antigens. 1997, vol. 49, no. 6, p. 624-628
Abstract HLA DRB1, DQA1 and DQB1 alleles were determined by DNA PCR-SSO typing in a sample of 99 individuals originating from Wielkopolska (midwestern Poland). A high number of alleles (38 DRB1, 8 DQA1 and 14 DQB1) was detected at each locus, many of them presenting notable frequencies in this population. The three HLA loci are thus characterized by very high heterozygosity levels (93% for DRB1, 85% for DQA1, and 88% for DQB1), which confirms the results found for other European populations. A total of 6 DRB1-DQA1-DQB1 haplotypes are detected with an estimated frequency higher than 5%, namely, DRB1*1501-DQA1*0102-DQB1*0602, DRB1*0701-DQA1*0201-DQB1*0201, DRB1*0101-DQA1*0101-DQB1*0501, DRB1*1101-DQA1*0501-DQB1*0301, DRB1*03011-DQA1*0501-DQB1*0201, and DRB1*1301-DQA1*0103-DQB1*0603. A genetic distance analysis between the Polish and other world populations tested for HLA class II indicates that the Wielkopolska community is close to geographically close, rather than linguistically related populations from Europe. More generally, a good agreement between genetics and geography is found for DRB1 and DQB1 polymorphisms in Europe, suggesting that these two loci are highly informative for assessing historical relationships among humans.
Keywords AllelesGene FrequencyHLA-DQ Antigens/geneticsHLA-DR Antigens/geneticsHaplotypesHumansPolandGenetic Polymorphism
PMID: 9234484
Full text
Article (Published version) (404 Kb) - public document Free access
Research group Unité d’anthropologie
(ISO format)
JUNGERMAN, M et al. HLA class II DRB1, DQA1 and DQB1 polymorphisms in the Polish population from Wielkopolska. In: Tissue Antigens, 1997, vol. 49, n° 6, p. 624-628. doi: 10.1111/j.1399-0039.1997.tb02810.x https://archive-ouverte.unige.ch/unige:17064

399 hits



Deposited on : 2011-09-30

Export document
Format :
Citation style :