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Title

HLA class II DNA polymorphism in a Moroccan population from the Souss, Agadir area

Authors
Izaabel, H
Garchon, H J
Caillat-Zucman, S
Beaurain, G
Akhayat, O
Bach, J F
Published in Tissue Antigens. 1998, vol. 51, no. 1, p. 106-10
Abstract HLA DRB1, DQA1 and DQB1 polymorphisms were analyzed by PCR-SSO typing in a sample of the Moroccan population from Souss. Uneven allelic frequency distributions are observed at each locus, with particularly high frequencies for DRB1*0701, DRB1*0301, DQA1*0501, DQA1*0201, and DQB1*0201. Only three haplotypes (DRB1*0701-DQA1*0201-DQB1*0201, DRB1*0301-DQA1*0501-DQB1*0201 and DRB1*11-DQA1*0501-DQB1*0301) account for nearly 50% of the total gene frequencies. A genetic distance analysis reveals that the Moroccan population is close to the Spanish and the Algerians, who live in geographically neighboring areas. However, the Souss population is also characterized by a lower level of genetic diversity compared to other African and European populations from the Mediterranean area. This may be the result of a rapid genetic drift due to their likely geographical and/or cultural isolation.
Keywords AllelesDNAGene FrequencyHLA-DQ Antigens/geneticsHLA-DR Antigens/geneticsHistocompatibility Antigens Class II/geneticsHumansMorocco/ethnologyGenetic PolymorphismPopulation
Identifiers
PMID: 9459511
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Article (Published version) (429 Kb) - public document Free access
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Research group Unité d’anthropologie
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IZAABEL, H et al. HLA class II DNA polymorphism in a Moroccan population from the Souss, Agadir area. In: Tissue Antigens, 1998, vol. 51, n° 1, p. 106-10. https://archive-ouverte.unige.ch/unige:17063

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Deposited on : 2011-09-30

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