Doctoral thesis
Open access

Regulation of Plasmodium Gametogenesis

ContributorsBalestra, Aurélia
Imprimatur date2021-12-15

Malaria is a major public health issue, responsible for 400 000 deaths every year. It is caused by Plasmodium parasites that circulate between vertebrate hosts and mosquito vectors. During this thesis, I focused on gametogenesis, a fascinating developmental stage to study Ca2+ signalling and regulation of the cell cycle in Plasmodium. Within seconds of activation, the cGMP- dependent protein kinase G (PKG) leads to mobilization of intracellular Ca2+. This is followed by a cascade of signalling events that in the male gametocyte regulates cell cycle progression to produce eight flagellated male gametes within ~10-12 minutes of the initial activation. I have identified a cGMP signalling platform involved in sensing extracellular cues activating gametogenesis and discovered a putative Ca2+ channel. Altogether my work sheds light into how Plasmodium transitions between host and vector and how it integrates and transduces cues from its environment to time its development.

Citation (ISO format)
BALESTRA, Aurélia. Regulation of <i>Plasmodium</i> Gametogenesis. 2021. doi: 10.13097/archive-ouverte/unige:170256
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Creation07/20/2023 5:55:17 AM
First validation07/20/2023 12:27:25 PM
Update time07/20/2023 12:27:25 PM
Status update07/20/2023 12:27:25 PM
Last indexation02/01/2024 10:23:44 AM
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