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Scientific article
Open access
English

Factors influencing scar formation following Bacille Calmette-Guérin (BCG) vaccination

Published inHeliyon, vol. 9, no. 4, e15241
Errata
  • Erratum in : Villanueva P, Crawford NW, Croda MG, Collopy S, Jardim BA, de Almeida Pinto Jardim T, Manning L, Lucas M, Marshall H, Prat-Aymerich C, Sawka A, Sharma K, Troeman D, Wadia U, Warris A, Wood N, Messina NL, Curtis N, Pittet LF. Erratum: Factors influencing scar formation following Bacille Calmette-Guérin (BCG) vaccination. Heliyon. 2023 Apr 26;9(6):e15821. doi: 10.1016/j.heliyon.2023.e15821.
  • DOI : 10.1016/j.heliyon.2023.e15821
  • PMID : 37484338
Publication date2023-04
First online date2023-04-06
Abstract

The prevalence of scar formation following Bacille Calmette-Guérin (BCG) vaccination varies globally. The beneficial off-target effects of BCG are proposed to be stronger amongst children who develop a BCG scar. Within an international randomised trial ('BCG vaccination to reduce the impact of coronavirus disease 2019 (COVID-19) in healthcare workers'; BRACE Trial), this nested prospective cohort study assessed the prevalence of and factors influencing scar formation, as well as participant perception of BCG scarring 12 months following vaccination . Amongst 3071 BCG-recipients, 2341 (76%) developed a BCG scar. Scar prevalence was lowest in Spain and highest in UK. Absence of post-injection wheal (OR 0.4, 95%CI 0.2-0.9), BCG revaccination (OR 1.7, 95%CI 1.3-2.0), female sex (OR 2.0, 95%CI 1.7-2.4), older age (OR 0.4, 95%CI 0.4-0.5) and study country (Brazil OR 1.6, 95%CI 1.3-2.0) influenced BCG scar prevalence. Of the 2341 participants with a BCG scar, 1806 (77%) did not mind having the scar. Participants more likely to not mind were those in Brazil, males and those with a prior BCG vaccination history. The majority (96%) did not regret having the vaccine. Both vaccination-related (amenable to optimisation) and individual-related factors affected BCG scar prevalence 12 months following BCG vaccination of adults, with implications for maximising the effectiveness of BCG vaccination.

eng
Keywords
  • BCG scar
  • BCG vaccine
  • Vaccination technique
  • Vaccine safety
Citation (ISO format)
VILLANUEVA, Paola et al. Factors influencing scar formation following Bacille Calmette-Guérin (BCG) vaccination. In: Heliyon, 2023, vol. 9, n° 4, p. e15241. doi: 10.1016/j.heliyon.2023.e15241
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ISSN of the journal2405-8440
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Technical informations

Creation05/12/2023 8:00:13 AM
First validation07/19/2023 2:39:34 PM
Update time04/30/2024 8:50:45 AM
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