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Doctoral thesis
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English

MRI Applications for Transplantation: Organ Preservation Techniques and Pre-Transplant Ex-Vivo Viability Assessment and Improved Phosphorus Magnetic Resonance Spectroscopic Imaging using Accelerated non-Fourier Reconstruction Techniques, and Artificial Intelligence

ContributorsSongeon, Julien
Number of pages211
Imprimatur date2023
Defense date2023
Abstract

The field of transplantation currently faces a significant challenge of organ shortage. In Switzerland, the number of patients waiting for transplantation surpasses 1435, while only 342 transplants were performed in 2022, amounting to a mere 20% of the number of waiting patients. To address this problem, marginal donors, extended-criteria donors (ECD), and donation after circulatory death (DCD) donors are being considered as alternative sources. However, the utilization of such donors is limited by the absence of a reliable and non-invasive method for evaluating kidney viability. Phosphorus magnetic resonance spectroscopy (31P-MRS) is a non-invasive technique that can detect high-energy phosphate metabolites in the kidney and provide insight into its energetic metabolism. This technique can identify several crucial metabolites, which may serve as significant biomarkers for graft viability. Due to its non-invasive nature, 31P-MRS represents a promising approach for monitoring mitochondrial function and predicting graft viability. The objective of this project is to implement the proposed methodology in actual clinical scenarios, with the aim of enhancing kidney preservation and improving 31P-MRSI into a practical approach for evaluating organ viability.

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Citation (ISO format)
SONGEON, Julien. MRI Applications for Transplantation: Organ Preservation Techniques and Pre-Transplant Ex-Vivo Viability Assessment and Improved Phosphorus Magnetic Resonance Spectroscopic Imaging using Accelerated non-Fourier Reconstruction Techniques, and Artificial Intelligence. 2023. doi: 10.13097/archive-ouverte/unige:170068
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Creation07/10/2023 8:59:55 AM
First validation07/11/2023 10:14:03 AM
Update time08/16/2023 8:34:53 AM
Status update08/16/2023 8:34:53 AM
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