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Scientific article
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English

Regulation of the microtubule network; the shaft matters!

Published inCurrent opinion in systems biology, vol. 34, p. 1-6; 100457
Publication date2023-06
Abstract

In cells, the microtubule network continually assembles and disassembles. The regulation of microtubule growth or shortening has almost exclusively been studied at their dynamic ends. However, microtubules are dynamic all along their entire shaft. A dynamic shaft increases the lifetime and length of a microtubule by reducing the shortening phases and promoting its regrowth. Here, we discuss how shaft dynamics can regulate microtubule network organization, intracellular transport, and polarization of the network.

eng
Keywords
  • Microtubule network
  • Kinesin-1
  • Microtubule lifetime
  • Microtubule repair
  • Microtubule damage
Research group
Citation (ISO format)
MEHIDI, Amine, AUMEIER, Charlotte. Regulation of the microtubule network; <i>the shaft matters!</i>. In: Current opinion in systems biology, 2023, vol. 34, p. 1–6. doi: 10.1016/j.coisb.2023.100457
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ISSN of the journal2452-3100
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Creation07/03/2023 9:44:39 AM
First validation07/04/2023 1:08:50 PM
Update time07/04/2023 1:08:50 PM
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