The objective of this work was to evaluate (1) the short-term evolution of pain and (2) the treatment success of full pulpotomy as permanent treatment of irreversible pulpitis in mature molars. The study consisted of a non-randomized comparison between a test group (n= 44)-full pulpotomy performed by non-specialist junior practitioners, and a control group (n= 40)-root canal treatments performed by specialized endodontists. Short-term pain score (Heft-Parker scale) was recorded pre-operatively, then at 24 h and 7 days post-operatively. Three outcomes were considered for treatment success:radiographic,clinicalandglobalsuccess. For short-term evolution of pain, a non-parametric Wilcoxon test was performed (significance level = 0.05). For treatment success, a Pearson Chi square or Fisher test were performed (significance level = 0.017-Bonferroni correction). There was no significant difference betweentestand control groups neither regarding short term evolution of pain at each time point, nor regardingclinical(80% and 90%, respectively) orglobalsuccess (77% and 67%, respectively). However, a significant difference inradiographicsuccess was observed (94% and 69%, respectively). The present work adds to the existing literature to support that pulpotomy as permanent treatment could be considered as an acceptable and conservative treatment option, potentially applied by a larger population of dentists.