Species Distribution Models (SDM) represent a powerful tool to predict species’ habitat suitability on a landscape and fill the gap between truncated observation data and all possible locations. SDMs have been widely used in theoretical studies of species niches as well as in conservation applications. Here, we evaluated the impacts of predictors’ type on models’ performances and spatial predictions using 72 plant species belonging to six ecological groups at a regional scale in the area of Geneva (Switzerland). Twelve models were created using various combinations of high-resolution (25 m) explanatory variables including topography, pedology, climate, habitats and remote sensing data. Models integrating a combination of habitats and topopedo-climatic predictors had significantly higher performances, while remote sensing predictors showed low performances. Our results suggest that the number and the level of details of habitat predictors (broad or very precise) do not fundamentally affect prediction maps. However, selecting too few, overly simplified or exceedingly complex habitat predictors tend to lower models’ performances. The use of eight habitat categories complemented with eight topopedo-climatic predictors produced models with the highest performances. Ecological groups of species responded differently to models and while alpine and ruderal species have greater average performances due to a high affinity with topopedo-climatic predictors, wetlands’ species were less performant on average. These results underline the necessity of developing or having access to habitats distribution data especially in a conservation context.