Scientific article

Clinical and economic impacts of explicit tools detecting prescribing errors: A systematic review

Published inJournal of clinical pharmacy and therapeutics, vol. 46, no. 4, p. 877-886
Publication date2021-08
First online date2021-03-25

What is known and objective: Many explicit tools have been developed to reduce prescribing errors and ensure patients' safety. The impact of explicit tools is not well studied. The objective of this study was (a) to conduct a systematic review of systematic reviews listing explicit tools developed to detect prescribing errors and (b) to assess their impact on clinical and economic outcomes.

Methods: This project includes two related parts. First, a systematic review of systematic reviews listing explicit tools dedicated to geriatrics or internal medicine was performed to develop an exhaustive list of explicit tools. Then, using the list compiled in the first step, a systematic review of randomized controlled trials (RCT) assessing clinical or economic impacts of tools was performed to evaluate their usefulness.

Results and discussion: The systematic review of systematic reviews identified 49 explicit tools. The systematic review of RCT, using one or more of the 49 explicit tools, identified 5 RCT using explicit tools as intervention (3 STOPP/START and 2 FORTA RCT). The 5 studies evaluated clinical impacts with 3 RCT identifying significant clinical impacts (falls, activities of daily living and/or adverse drug reactions) and 2 STOPP/START RCT identifying significant economic impacts.

What is new and conclusion: The systematic review of RCT showed that explicit tools can have some effect in improving patients' safety. Further studies are warranted to better characterize their clinical and economic impact.

  • Explicit tools
  • Inappropriate prescribing
  • Potentially inappropriate medication list
  • Randomized controlled trial
  • Systematic review
  • Accidental Falls / economics
  • Accidental Falls / statistics & numerical data
  • Activities of Daily Living
  • Drug Prescriptions / statistics & numerical data
  • Geriatrics
  • Humans
  • Inappropriate Prescribing
  • Internal Medicine
  • Medication Errors / economics
  • Medication Errors / statistics & numerical data
  • Medication Reconciliation
  • Medication Therapy Management
  • Polypharmacy
  • Prescription Drugs / economics
  • Quality of Life
  • Randomized Controlled Trials as Topic
Citation (ISO format)
FARHAT, Akram et al. Clinical and economic impacts of explicit tools detecting prescribing errors: A systematic review. In: Journal of clinical pharmacy and therapeutics, 2021, vol. 46, n° 4, p. 877–886. doi: 10.1111/jcpt.13408
Main files (1)
Article (Published version)
ISSN of the journal0269-4727

Technical informations

Creation03/27/2023 10:54:46 AM
First validation06/23/2023 8:57:08 AM
Update time06/23/2023 8:57:08 AM
Status update06/23/2023 8:57:08 AM
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