Scientific article
Open access

Global survival trends for brain tumors, by histology: Analysis of individual records for 67,776 children diagnosed in 61 countries during 2000–2014 (CONCORD-3)

Published inNeuro-oncology, vol. 25, no. 3, p. 593-606
Publication date2023-03-01
First online date2022-10-10

Introduction: Tumors of the central nervous system are among the leading causes of cancer-related death in children. Population-based cancer survival reflects the overall effectiveness of a health care system in managing cancer. Inequity in access to care world-wide may result in survival disparities.

Methods: We considered children (0-14 years) diagnosed with a brain tumor during 2000-2014, regardless of tumor behavior. Data underwent a rigorous, three-phase quality control as part of CONCORD-3. We implemented a revised version of the International Classification of Childhood Cancer (third edition) to control for under-registration of non-malignant astrocytic tumors. We estimated net survival using the unbiased nonparametric Pohar Perme estimator.

Results: The study included 67,776 children. We estimated survival for 12 histology groups, each based on relevant ICD-O-3 codes. Age-standardized 5-year net survival for low-grade astrocytoma ranged between 84% and 100% world-wide during 2000-2014. In most countries, 5-year survival was 90% or more during 2000-2004, 2005-2009, and 2010-2014. Global variation in survival for medulloblastoma was much wider, with age-standardized 5-year net survival between 47% and 86% for children diagnosed during 2010-2014.

Conclusions: To the best of our knowledge, this study provides the largest account to date of global trends in population-based survival for brain tumors in children, by histology. We devised an enhanced version of ICCC-3 to account for differences in cancer registration practices world-wide. Our findings may have public health implications, because low-grade glioma is 1 of the 6 index childhood cancers included by WHO in the Global Initiative for Childhood Cancer.

  • Brain tumor
  • Cancer registries
  • Childhood cancer
  • International comparisons
  • Survival
  • Brain Neoplasms / epidemiology
  • Child
  • Delivery of Health Care
  • Humans
  • Institut National du Cancer -
  • US National Cancer Institute -
  • American Cancer Society -
  • Centers for Disease Control and Prevention -
  • Susan G Komen Foundation -
  • Swiss Cancer Research Foundation -
  • Children with Cancer UK -
  • Rossy Family Foundation -
  • La Ligue Contre le Cancer -
  • Swiss Cancer League -
Citation (ISO format)
GIRARDI, Fabio et al. Global survival trends for brain tumors, by histology: Analysis of individual records for 67,776 children diagnosed in 61 countries during 2000–2014 (CONCORD-3). In: Neuro-oncology, 2023, vol. 25, n° 3, p. 593–606. doi: 10.1093/neuonc/noac232
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Article (Published version)
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ISSN of the journal1522-8517

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Creation06/20/2023 2:57:52 PM
First validation06/21/2023 2:00:49 PM
Update time06/21/2023 2:00:49 PM
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