Scientific article
Open access

Impact of SARS-CoV2 infection on anti-apolipoprotein A-1 IgG response in inflammatory rheumatic diseases

Published inFrontiers in immunology, vol. 14, 1154058
Publication date2023-05-10
First online date2023-05-10

Objectives: To investigate the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection on anti-apolipoprotein A-1 IgG (AAA1) humoral response in immunosuppressed inflammatory rheumatic diseases (IRD) patients.

Methods: This is a nested cohort study from the prospective Swiss Clinical Quality Management registry. A total of 368 IRD patients for which serum samples were available before and after the SARS-CoV2 pandemic were included. Autoantibodies against ApoA-1 (AAA1) and its c-terminal region (AF3L1) were measured in both samples. The exposure of interest was anti-SARS-CoV2 spike subunit 1 (S1) seropositivity measured in the second sample. The effect of SARS-CoV2 infection (anti-S1 seropositivity) on becoming AAA1 or AF3L1 positive and on the change of AAA1 or AF3L1 optical density (OD) between the two samples was tested with multivariable regressions.

Results: There were 12 out of 368 IRD patients who were seroconverted against S1. The proportion of patients becoming AF3L1 seropositive was significantly higher in anti-S1-positive patients, compared with anti-S1-negative patients (66.7% versus 21.6%, p = 0.001). Adjusted logistic regression analyses indicated that anti-S1 seroconversion was associated with a sevenfold increased risk of AFL1 seropositivity (odds ratio: 7.4, 95% confidence interval (95% CI): 2.1-25.9) and predicted median increase in AF3L1 OD values (+0.17, 95% CI: 0.08-0.26).

Conclusions: SARS-CoV2 infection is associated with a marked humoral response against the immunodominant c-terminal region of ApoA-1 in IRD patients. The possible clinical impact of AAA1 and AF3L1 antibodies on disease progression, cardiovascular complications, or long COVID syndrome deserves future investigations.

  • Anti-apolipoprotein A-1 IgG
  • Autoantibodies
  • Autoimmunity
  • Inflammatory rheumatic diseases
  • Severe acute respiratory syndrome coronavirus 2
  • Apolipoprotein A-I
  • COVID-19
  • Cohort Studies
  • Humans
  • Immunoglobulin G
  • Post-Acute COVID-19 Syndrome
  • Prospective Studies
  • Rheumatic Fever
  • SARS-CoV-2
Citation (ISO format)
LAMACCHIA, Céline et al. Impact of SARS-CoV2 infection on anti-apolipoprotein A-1 IgG response in inflammatory rheumatic diseases. In: Frontiers in immunology, 2023, vol. 14, p. 1154058. doi: 10.3389/fimmu.2023.1154058
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Article (Published version)
ISSN of the journal1664-3224

Technical informations

Creation06/06/2023 12:13:18 PM
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