Scientific article

Personality Impact on Alzheimer's Disease - Signature and Vascular Imaging Markers: A PET-MRI Study

Published inJournal of Alzheimer's disease, vol. 85, no. 4, p. 1807-1817
Publication date2022
First online date2022-02-15

Background: Several studies postulated that personality is an independent determinant of cognitive trajectories in old age.

Objective: This study explores the impact of personality on widely used Alzheimer's disease (AD) and vascular imaging markers.

Methods: We examined the association between personality and three classical AD imaging markers (centiloid-based-amyloid load, MRI volumetry in hippocampus, and media temporal lobe atrophy), and two vascular MRI parameters (Fazekas score and number of cortical microbleeds) assessed at baseline and upon a 54-month-follow-up. Personality was assessed with the Neuroticism Extraversion Openness Personality Inventory-Revised. Regression models were used to identify predictors of imaging markers including sex, personality factors, presence of APOE ɛ4 allele and cognitive evolution over time.

Results: Cortical GM volumes were negatively associated with higher levels of Conscientiousness both at baseline and follow-up. In contrast, higher scores of Openness were related to better preservation of left hippocampal volumes in these two time points and negatively associated with medial temporal atrophy at baseline. Amyloid load was not affected by personality factors. Cases with higher Extraversion scores displayed higher numbers of cortical microbleeds at baseline.

Conclusion: Personality impact on brain morphometry is detected only in some among the routinely used imaging markers. The most robust associations concern the positive role of high levels of Conscientiousness and Openness on AD-signature MRI markers. Higher extraversion levels are associated with increased vulnerability to cortical microbleeds pointing to the fact that the socially favorable traits may have a detrimental effect on brain integrity in old age.

  • Amyloid load
  • Cortical volume
  • Gray matter density
  • Normal aging
  • Personality
  • Aged
  • Alzheimer Disease / pathology
  • Atrophy / pathology
  • Brain / pathology
  • Female
  • Hippocampus / pathology
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging
  • Male
  • Neuropsychological Tests
  • Personality / physiology
  • Personality Inventory
  • Positron-Emission Tomography
  • Temporal Lobe / pathology
Citation (ISO format)
GIANNAKOPOULOS, Panteleimon et al. Personality Impact on Alzheimer’s Disease - Signature and Vascular Imaging Markers: A PET-MRI Study. In: Journal of Alzheimer’s disease, 2022, vol. 85, n° 4, p. 1807–1817. doi: 10.3233/JAD-215062
Main files (1)
Article (Published version)
ISSN of the journal1387-2877

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