Scientific article
Open access

Interleukin-18 in metabolism: from mice physiology to human diseases

Published inFrontiers in endocrinology, vol. 13, 971745
  • An omission to the funding section of the original article was made in error. The following sentence has been added: “Open access funding was provided by the University of Geneva”. The original version of this article has been updated.
  • DOI : 10.3389/fendo.2022.971745
  • PMID : 36967800
Publication date2022-10-12
First online date2022-10-12

Interleukin-18 (IL-18) is a classical member of the IL-1 superfamily of cytokines. As IL-1β, IL-18 precursor is processed by inflammasome/caspase-1 into a mature and biologically active form. IL-18 binds to its specific receptor composed of two chains (IL-18Rα and IL-18Rβ) to trigger a similar intracellular signaling pathway as IL-1, ultimately leading to activation of NF-κB and inflammatory processes. Independently of this IL-1-like signaling, IL-18 also specifically induces IFN-γ production, driving the Th1 immune response. In circulation, IL-18 binds to the IL-18 binding protein (IL-18BP) with high affinity, letting only a small fraction of free IL-18 able to trigger receptor-mediated signaling. In contrast to other IL-1 family members, IL-18 is produced constitutively by different cell types, suggesting implications in normal physiology. If the roles of IL-18 in inflammatory processes and infectious diseases are well described, recent experimental studies in mice have highlighted the action of IL-18 signaling in the control of energy homeostasis, pancreatic islet immunity and liver integrity during nutritional stress. At the same time, clinical observations implicate IL-18 in various metabolic diseases including obesity, type 1 and 2 diabetes and nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH). In the present review, we summarize and discuss both the physiological actions of IL-18 in metabolism and its potential roles in pathophysiological mechanisms leading to the most common human metabolic disorders, such as obesity, diabetes and NAFLD/NASH.

  • NASH
  • Diabetes mellitus
  • Gut microbiota
  • Inflammation
  • Interleukin-18
  • Obesity
  • Animals
  • Diabetes Mellitus, Type 1
  • Diabetes Mellitus, Type 2
  • Humans
  • Interleukin-18
  • Mice
  • Non-alcoholic Fatty Liver Disease / metabolism
  • Obesity
Citation (ISO format)
SOMM, Emmanuel, JORNAYVAZ, François. Interleukin-18 in metabolism: from mice physiology to human diseases. In: Frontiers in endocrinology, 2022, vol. 13, p. 971745. doi: 10.3389/fendo.2022.971745
Main files (1)
Article (Published version)
Updates (1)
ISSN of the journal1664-2392

Technical informations

Creation03/22/2023 9:22:57 AM
First validation06/01/2023 7:04:57 AM
Update time06/01/2023 7:04:57 AM
Status update06/01/2023 7:04:57 AM
Last indexation08/31/2023 11:21:22 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack