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Scientific article
English

A novel hepatitis C virus (HCV) subtype from Somalia and its classification into HCV clade 3

Published inJournal of general virology, vol. 81, no. 6, p. 1485-1493
Publication date2000
Abstract

Hepatitis C virus (HCV) sequences from throughout the world have been grouped into six clades, based on recently proposed criteria. Here, the partial sequences and clade assignment are reported for three HCV isolates from chronic hepatitis C patients from Somalia, for whom conventional assays failed to identify the genotype. Phylogenetic analysis of the sequences of the core, envelope 1 and part of the non- structural 5b regions suggests that all three isolates belong to a distinct HCV genetic group, tentatively classified as subtype 3h. This novel HCV subtype shows the highest sequence similarity with HCV isolates from Indonesia. Despite the fact that these patients were infected with HCV clade 3, none of them responded to standard interferon treatment.

Keywords
  • Adult
  • Base Sequence
  • DNA, Viral
  • Female
  • Genotype
  • Hepacivirus/classification/genetics
  • Hepatitis C, Chronic/virology
  • Humans
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Phylogeny
  • Sequence Analysis, DNA
  • Sequence Homology, Nucleic Acid
  • Somalia
  • Viral Core Proteins/genetics
  • Viral Envelope Proteins/genetics
  • Viral Nonstructural Proteins/genetics
Citation (ISO format)
ABID, Karim et al. A novel hepatitis C virus (HCV) subtype from Somalia and its classification into HCV clade 3. In: Journal of general virology, 2000, vol. 81, n° 6, p. 1485–1493. doi: 10.1099/0022-1317-81-6-1485
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ISSN of the journal0022-1317
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