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Scientific article
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Outcome and Prognostic Factors of COVID-19 Infection in Swiss Cancer Patients: Final Results of SAKK 80/20 (CaSA)

Published inCancers, vol. 14, no. 9, 2191
Publication date2022-04-27
First online date2022-04-27
Abstract

Purpose: These are the final results of a national registry on cancer patients with COVID-19 in Switzerland.

Methods: We collected data on symptomatic COVID-19-infected cancer patients from 23 Swiss sites over a one-year period starting on 1 March 2020. The main objective was to assess the outcome (i.e., mortality, rate of hospitalization, ICU admission) of COVID-19 infection in cancer patients; the main secondary objective was to define prognostic factors.

Results: From 455 patients included, 205 patients (45%) had non-curative disease, 241 patients (53%) were hospitalized for COVID-19, 213 (47%) required oxygen, 43 (9%) invasive ventilation and 62 (14%) were admitted to the ICU. Death from COVID-19 infection occurred in 98 patients, resulting in a mortality rate of 21.5%. Age ≥65 years versus <65 years (OR 3.14,p= 0.003), non-curative versus curative disease (OR 2.42,p= 0.012), ICU admission (OR 4.45,p< 0.001) and oxygen requirement (OR 20.28,p< 0.001) were independently associated with increased mortality.

Conclusions: We confirmed high COVID-19 severity and mortality in real-world cancer patients during the first and second wave of the pandemic in a country with a decentralized, high-quality, universal-access health care system. COVID-19-associated mortality was particularly high for those of older age in a non-curative disease setting, requiring oxygen or ICU care.

eng
Keywords
  • COVID-19
  • Cancer
  • Cancer treatment
  • Coronavirus
  • Pandemic
Citation (ISO format)
JOERGER, Markus et al. Outcome and Prognostic Factors of COVID-19 Infection in Swiss Cancer Patients: Final Results of SAKK 80/20 (CaSA). In: Cancers, 2022, vol. 14, n° 9, p. 2191. doi: 10.3390/cancers14092191
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Article (Published version)
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ISSN of the journal2072-6694
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