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Scientific article
Open access
English

Serum NGAL, BNP, PTH, and albumin do not improve glomerular filtration rate estimating formulas in children

Published inEuropean journal of pediatrics, vol. 180, no. 7, p. 2223-2228
Publication date2021-07
First online date2021-03-10
Abstract

Glomerular filtration rate (GFR) is difficult to measure, and estimating formulas are notorious for lacking precision. This study aims to assess if the inclusion of additional biomarkers improves the performance of eGFR formulas. A hundred and sixteen children with renal diseases were enrolled. Data for age, weight, height, inulin clearance (iGFR), serum creatinine, cystatin C, neutrophil gelatinase-associated lipocalin (NGAL), parathyroid hormone (PTH), albumin, and brain natriuretic peptide (BNP) were collected. These variables were added to the revised and combined (serum creatinine and cystatin C) Schwartz formulas, and the quadratic and combined quadratic formulas. We calculated the adjusted r-square (r2) in relation to iGFR and tested the improvement in variance explained by means of the likelihood ratio test. The combined Schwartz and the combined quadratic formulas yielded best results with an r2 of 0.676 and 0.730, respectively. The addition of BNP and PTH to the combined Schwartz and quadratic formulas improved the variance slightly. NGAL and albumin failed to improve the prediction of GFR further. These study results also confirm that the addition of cystatin C improves the performance of estimating GFR formulas, in particular the Schwartz formula.

eng
Keywords
  • Albumin
  • Brain natriuretic peptide
  • Child
  • Glomerular filtration rate
  • Neutrophil gelatinase-associated lipocalin
  • Parathyroid hormone
  • Albumins
  • Biomarkers
  • Creatinine
  • Glomerular Filtration Rate
  • Humans
  • Lipocalin-2
  • Natriuretic Peptide, Brain
  • Parathyroid Hormone
Citation (ISO format)
MOURON-HRYCIUK, Julie et al. Serum NGAL, BNP, PTH, and albumin do not improve glomerular filtration rate estimating formulas in children. In: European journal of pediatrics, 2021, vol. 180, n° 7, p. 2223–2228. doi: 10.1007/s00431-021-04019-w
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Article (Published version)
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ISSN of the journal0340-6199
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