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Scientific article
Open access
English

Use of statins after liver transplantation is associated with improved survival: results of a nationwide study

Published inAlimentary pharmacology & therapeutics, vol. 56, no. 7, p. 1194-1204
Publication date2022-10
First online date2022-08-18
Abstract

Background: There is limited information on the effects of statins on the outcomes of liver transplantation (LT), regarding either their use by LT recipients or donors.

Aim: To analyse the association between statin exposure and recipient and graft survival.

Methods: We included adult LT recipients with deceased donors in a nationwide prospective database study. Using a multistate modelling approach, we examined the effect of statins on the transition hazard between LT, biliary and vascular complications and death, allowing for recurring events. The observation time was 3 years.

Results: We included 998 (696 male, 70%, mean age 54.46 ± 11.14 years) LT recipients. 14% of donors and 19% of recipients were exposed to statins during the study period. During follow-up, 141 patients died; there were 40 re-LT and 363 complications, with 66 patients having two or more complications. Treatment with statins in the recipient was modelled as a concurrent covariate and associated with lower mortality after LT (HR = 0.35; 95% CI 0.12-0.98; p = 0.047), as well as a significant reduction of re-LT (p = 0.004). However, it was not associated with lower incidence of complications (HR = 1.25; 95% CI = 0.85-1.83; p = 0.266). Moreover, in patients developing complications, statin use was significantly associated with decreased mortality (HR = 0.10; 95% CI = 0.01-0.81; p = 0.030), and reduced recurrence of complications (HR = 0.43; 95% CI = 0.20-0.93; p = 0.032).

Conclusions: Statin use by LT recipients may confer a survival advantage. Statin administration should be encouraged in LT recipients when clinically indicated.

eng
Keywords
  • Cardiovascular disease
  • Dyslipidemia
  • Solid organ transplantation
  • Survival
  • Adult
  • Aged
  • Graft Survival
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
  • Liver Transplantation
  • Male
  • Middle Aged
  • Retrospective Studies
  • Risk Factors
  • Treatment Outcome
Citation (ISO format)
BECCHETTI, Chiara et al. Use of statins after liver transplantation is associated with improved survival: results of a nationwide study. In: Alimentary pharmacology & therapeutics, 2022, vol. 56, n° 7, p. 1194–1204. doi: 10.1111/apt.17192
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Article (Published version)
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Identifiers
ISSN of the journal0269-2813
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