Scientific article
Open access

Evaluation of models for the mechanism of action of 4-hydroxyphenylpyruvate dioxygenase

Published inExperientia, vol. 37, no. 11, p. 1134-1137
Publication date1981-11-15

4-Hydroxyphenylpyruvic acid was oxygenated with various complexes of oxygen with Fe2+, superoxide ion, hydroperoxide anion, triplet and singlet oxygen. Oxidation occurred giving varying amounts of the 4-hydroxy derivatives of benzaldehyde, benzoic acid, phenol, phenylacetic acid and 4-carboxymethylquinone, but no homogentisic acid. 4-Hydroxyphenylperacetic acid was prepared and shown not to undergo self-oxidation. Its ferrous salt decomposed to 4-hydroxybenzyl alcohol. It is concluded that the alpha-keto carboxylic function is the site of oxygenation in the enzyme process and that a trioxalanone rather than a peracid intermediate may be implicated.

  • 4-Hydroxyphenylpyruvate Dioxygenase / metabolism
  • Iron
  • Models, Chemical
  • Oxygen
  • Oxygenases / metabolism
Citation (ISO format)
JEFFORD, Charles, CADBY, Peter Alan. Evaluation of models for the mechanism of action of 4-hydroxyphenylpyruvate dioxygenase. In: Experientia, 1981, vol. 37, n° 11, p. 1134–1137. doi: 10.1007/BF01989880
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Article (Published version)
ISSN of the journal0014-4754

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