Background: Although high-frequency percussive ventilation (HFPV) improves gas exchange, concerns remain about tissue overdistension caused by the oscillations and consequent lung damage. We compared a modified percussive ventilation modality created by superimposing high-frequency oscillations to the conventional ventilation waveform during expiration only (eHFPV) with conventional mechanical ventilation (CMV) and standard HFPV.

Methods: Hypoxia and hypercapnia were induced by decreasing the frequency of CMV in New Zealand White rabbits (n = 10). Following steady-state CMV periods, percussive modalities with oscillations randomly introduced to the entire breathing cycle (HFPV) or to the expiratory phase alone (eHFPV) with varying amplitudes (2 or 4 cmH₂O) and frequencies were used (5 or 10 Hz). The arterial partial pressures of oxygen (PaO₂) and carbon dioxide (PaCO₂) were determined. Volumetric capnography was used to evaluate the ventilation dead space fraction, phase 2 slope, and minute elimination of CO₂. Respiratory mechanics were characterized by forced oscillations.

Results: The use of eHFPV with 5 Hz superimposed oscillation frequency and an amplitude of 4 cmH₂O enhanced gas exchange similar to those observed after HFPV. These improvements in PaO₂ (47.3 ± 5.5 vs. 58.6 ± 7.2 mmHg) and PaCO₂ (54.7 ± 2.3 vs. 50.1 ± 2.9 mmHg) were associated with lower ventilation dead space and capnogram phase 2 slope, as well as enhanced minute CO₂ elimination without altering respiratory mechanics.

Conclusions: These findings demonstrated improved gas exchange using eHFPV as a novel mechanical ventilation modality that combines the benefits of conventional and small-amplitude high-frequency oscillatory ventilation, owing to improved longitudinal gas transport rather than increased lung surface area available for gas exchange.