en
Scientific article
Data paper
Open access
English

Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers

ContributorsCohen-Adad, Julienorcid; Alonso-Ortiz, Eva; Abramovic, Mihael; Arneitz, Carina; Atcheson, Nicoleorcid; Barlow, Laura; Barry, Robert L.; Barth, Markusorcid; Battiston, Marco; Büchel, Christianorcid; Budde, Matthew; Callot, Virginieorcid; Combes, Anna J. E.; De Leener, Benjamin; Descoteaux, Maxime; de Sousa, Paulo Loureiroorcid; Dostál, Marekorcid; Doyon, Julien; Dvorak, Adamorcid; Eippert, Falk; Epperson, Karla R.; Epperson, Kevin S.; Freund, Patrickorcid; Finsterbusch, Jürgen; Foias, Alexandru; Fratini, Michela; Fukunaga, Issei; Gandini Wheeler-Kingshott, Claudia A. M.; Germani, Giancarlo; Gilbert, Guillaume; Giove, Federicoorcid; Gros, Charleyorcid; Grussu, Francesco; Hagiwara, Akifumi; Henry, Pierre-Gilles; Horák, Tomáš; Hori, Masaakiorcid; Joers, Jamesorcid; Kamiya, Kouhei; Karbasforoushan, Halehorcid; Keřkovský, Miloš; Khatibi, Aliorcid; Kim, Joo-Won; Kinany, Nawal; Kitzler, Hagen H.orcid; Kolind, Shannon; Kong, Yazhuoorcid; Kudlička, Petrorcid; Kuntke, Paul; Kurniawan, Nyoman D.orcid; Kusmia, Slawomirorcid; Labounek, Renéorcid; Laganà, Maria Marcellaorcid; Laule, Cornelia; Law, Christine S.orcid; Lenglet, Christopheorcid; Leutritz, Tobiasorcid; Liu, Yaou; Llufriu, Sara; Mackey, Seanorcid; Martinez-Heras, Eloyorcid; Mattera, Loan; Nestrasil, Igororcid; O’Grady, Kristin P.orcid; Papinutto, Nico; Papp, Daniel; Pareto, Deborahorcid; Parrish, Todd B.; Pichiecchio, Annaorcid; Prados, Ferranorcid; Rovira, Àlex; Ruitenberg, Marc J.orcid; Samson, Rebecca S.; Savini, Giovanniorcid; Seif, Maryam; Seifert, Alan C.; Smith, Alex K.; Smith, Seth A.; Smith, Zachary A.; Solana, Elisabeth; Suzuki, Y.; Tackley, Georgeorcid; Tinnermann, Alexandra; Valošek, Janorcid; Van De Ville, Dimitriorcid; Yiannakas, Marios C.; Weber II, Kenneth A.orcid; Weiskopf, Nikolausorcid; Wise, Richard G.; Wyss, Patrik O.; Xu, Junqian
Published inScientific data, vol. 8, no. 1, 219
Errata
Errata
Publication date2021-08-16
First online date2021-08-16
Abstract

In a companion paper by Cohen-Adad et al. we introduce the spine generic quantitative MRI protocol that provides valuable metrics for assessing spinal cord macrostructural and microstructural integrity. This protocol was used to acquire a single subject dataset across 19 centers and a multi-subject dataset across 42 centers (for a total of 260 participants), spanning the three main MRI manufacturers: GE, Philips and Siemens. Both datasets are publicly available via git-annex. Data were analysed using the Spinal Cord Toolbox to produce normative values as well as inter/intra-site and inter/intra-manufacturer statistics. Reproducibility for the spine generic protocol was high across sites and manufacturers, with an average inter-site coefficient of variation of less than 5% for all the metrics. Full documentation and results can be found at https://spine-generic.rtfd.io/. The datasets and analysis pipeline will help pave the way towards accessible and reproducible quantitative MRI in the spinal cord.

eng
Keywords
  • Adult
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging
  • Male
  • Neuroimaging
  • Reproducibility of Results
  • Spinal Cord / diagnostic imaging
  • Spinal Cord / ultrastructure
Funding
  • Multiple Sclerosis Society - [77]
  • Economic and Social Research Council - [ES/S011684/1]
  • NINDS NIH HHS - [K23 NS104211]
  • European Research Council - [758974]
  • NIBIB NIH HHS - [R00 EB016689]
  • Wellcome Trust - [203139/Z/16/Z]
  • Swiss National Science Foundation - Interactions between spinal cord and brain during impaired sensorimotor information flow after cervical spinal cord injury [181362]
  • European Commission - Deconstructing pain with predictive models: from neural architecture to pain relief [758974]
  • European Commission - Non-Invasive In-Vivo Histology in Health and Disease Using Magnetic Resonance Imaging (MRI) [616905]
  • European Commission - Antibodies against Nogo-A to enhance plasticity, regeneration and functional recovery after acute spinal cord injury, a multicenter European clinical proof of concept trial [681094]
  • European Commission - A Clinical Decision Support system based on Quantitative multimodal brain MRI for personalized treatment in neurological and psychiatric disorders [634541]
Citation (ISO format)
COHEN-ADAD, Julien et al. Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers. In: Scientific data, 2021, vol. 8, n° 1, p. 219. doi: 10.1038/s41597-021-00941-8
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Article (Published version)
Secondary files (3)
Identifiers
ISSN of the journal2052-4463
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