en
Scientific article
Open access
English

Revisiting brain rewiring and plasticity in children born without corpus callosum

Published inDevelopmental science, vol. 24, no. 6, e13126
Publication date2021-11
First online date2021-06-01
Abstract

The corpus callosum is the largest white matter pathway connecting homologous structures of the two cerebral hemispheres. Remarkably, children and adults with developmental absence of the corpus callosum (callosal dysgenesis, CD) show typical interhemispheric integration, which is classically impaired in adult split-brain patients, for whom the corpus callosum is surgically severed. Tovar-Moll and colleagues (2014) proposed alternative neural pathways involved in the preservation of interhemispheric transfer. In a sample of six adults with CD, they revealed two homotopic bundles crossing the midline via the anterior and posterior commissures and connecting parietal cortices, and the microstructural properties of these aberrant bundles were associated with functional connectivity of these regions. The aberrant bundles were specific to CD and not visualised in healthy brains. We extended this study in a developmental cohort of 20 children with CD and 29 typically developing controls (TDC). The two anomalous white-matter bundles were visualised using tractography. Associations between structural properties of these bundles and their regional functional connectivity were explored. The proposed atypical bundles were observed in 30% of our CD cohort crossing via the anterior commissure, and in 30% crossing via the posterior commissure (also observed in 6.9% of TDC). However, the structural property measures of these bundles were not associated with parietal functional connectivity, bringing into question their role and implication for interhemispheric functional connectivity in CD. It is possible that very early disruption of embryological callosal development enhances neuroplasticity and facilitates the formation of these proposed alternative neural pathways, but further evidence is needed.

eng
Keywords
  • Anterior commissure
  • Brain plasticity
  • Callosal dysgenesis
  • Functional connectivity
  • Posterior commissure
  • Tractography
  • Adult
  • Agenesis of Corpus Callosum
  • Brain
  • Child
  • Corpus Callosum
  • Humans
  • Neural Pathways
  • White Matter
Funding
  • European Commission - Identifying Predictors of Risk and Resilience for poor neuropsychological Outcome following childhood Brain InsulTs (PROBIt) [682734]
Citation (ISO format)
SIFFREDI, Vanessa et al. Revisiting brain rewiring and plasticity in children born without corpus callosum. In: Developmental science, 2021, vol. 24, n° 6, p. e13126. doi: 10.1111/desc.13126
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Article (Published version)
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Identifiers
ISSN of the journal1363-755X
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