Scientific article

Comparative study of FAST gradient echo MRI sequences: phantom study

Published inJournal of magnetic resonance imaging, vol. 20, no. 6, p. 1030-1038
Publication date2004-11-19

PURPOSE: To investigate a balanced steady state free precession sequence (b-SSFP) under a large range of conditions and to compare its performance with other types of gradient echo sequences for dynamic imaging.

MATERIALS AND METHODS: Balanced turbo field echo (b-TFE; Philips Medical Systems, Best, The Netherlands) was investigated in vitro at a range of T2/T1 along with T1-contrast enhanced turbo field echo (T1-TFE) and turbo field echo (TFE) so that a comparison could be made. Performance was quantified in terms of the initial slope of the signal-to-noise ratio (SNR) vs. 1/T1 curve (sensitivity) and the range of 1/T1 before signal saturation (contrast dynamic range [CDR]).

RESULTS: The b-TFE sequence was found to best perform, in terms of an optimal CDR, with a 90° flip angle (FA), saturation preparation, and short inversion time. Using these parameters, the sensitivity was also higher than that of the TFE sequence and T1-TFE sequence under their respective optimal conditions. For detection of small changes in contrast agent concentration (0.0-0.1 mM), b-TFE was also found to be the sequence of choice, with optimized parameters as follows, 90° FA, shortest TR/TE, and no magnetization preparation. The smallest matrices gave the highest signal sensitivity for all three sequences.

CONCLUSION: The CDR of b-TFE was much narrower than that of T1-TFE but could be widened under optimized conditions. The sensitivity of the b-TFE technique was the highest of the three sequences under all conditions tested.

  • Contrast Media / administration & dosage
  • Gadolinium DTPA / administration & dosage
  • Magnetic Resonance Imaging / methods
  • Phantoms, Imaging
  • Sensitivity and Specificity
Citation (ISO format)
PERRIN, Rosalind et al. Comparative study of FAST gradient echo MRI sequences: phantom study. In: Journal of magnetic resonance imaging, 2004, vol. 20, n° 6, p. 1030–1038. doi: 10.1002/jmri.20205
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Article (Published version)
ISSN of the journal1053-1807

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