Considerable efforts have been undertaken to quickly develop COVID-19 vaccines that protect vulnerable adults against severe disease and thus limit the socio-economic and public health impact of the current pandemic. To justify COVID-19 vaccination for the pediatric population, which rarely suffers from severe COVID-19, vaccines will need to have fully demonstrated safety and efficacy in preventing complications and viral transmission. This article summarizes the different vaccine platforms that are currently being tested and discusses practical and ethical aspects of childhood COVID-19 vaccination. It also examines the already deleterious effects of the pandemic on routine childhood vaccine coverage and insists on the imperative to vaccinate all children timely as recommended by national immunization programs.