Functional HPV-specific PD-1+ stem-like CD8 T cells in head and neck cancer
ContributorsEberhardt, Christiane Sigrid; Kissick, Haydn T
; Patel, Mihir R; Cardenas, Maria A; Prokhnevska, Nataliya; Obeng, Rebecca C
; Nasti, Tahseen H; Griffith, Christopher C; Im, Se Jin; Wang, Xu; Shin, Dongsuk; Carrington, Mary
; Chen, Zhuo G; Sidney, John; Sette, Alessandro; Saba, Nabil F; Wieland, Andreas
; Ahmed, Rafi





Published inNature, vol. 597, no. 7875, p. 279-284
Publication date2021-09
First online date2021-09-01
Abstract
Keywords
- Alphapapillomavirus / immunology
- Alphapapillomavirus / isolation & purification
- CD8-Positive T-Lymphocytes / classification
- CD8-Positive T-Lymphocytes / cytology
- CD8-Positive T-Lymphocytes / immunology
- CD8-Positive T-Lymphocytes / metabolism
- Cancer Vaccines / immunology
- Cell Differentiation
- Cell Proliferation
- DNA-Binding Proteins / immunology
- Head and Neck Neoplasms / immunology
- Head and Neck Neoplasms / virology
- Humans
- Lymphocytes, Tumor-Infiltrating / classification
- Lymphocytes, Tumor-Infiltrating / cytology
- Lymphocytes, Tumor-Infiltrating / immunology
- Lymphocytes, Tumor-Infiltrating / metabolism
- Oncogene Proteins, Viral / immunology
- Papillomavirus Infections / immunology
- Papillomavirus Infections / virology
- Papillomavirus Vaccines / immunology
- Programmed Cell Death 1 Receptor / metabolism
- RNA-Seq
- Receptors, Antigen, T-Cell / immunology
- Single-Cell Analysis
- Stem Cells / cytology
- Stem Cells / immunology
- T Cell Transcription Factor 1 / metabolism
- T-Lymphocytes / immunology
- Transcription, Genetic
Research group
Funding
- NCATS NIH HHS - [UL1 TR002378]
- NIH HHS - [2P30 CA138292-04]
- NIH HHS - [P51 OD011132]
- Swiss National Science Foundation - Characterization of B cell mediated immunity and longevity to VZV immunization [174483]
Citation (ISO format)
EBERHARDT, Christiane Sigrid et al. Functional HPV-specific PD-1<sup>+</sup> stem-like CD8 T cells in head and neck cancer. In: Nature, 2021, vol. 597, n° 7875, p. 279–284. doi: 10.1038/s41586-021-03862-z
Main files (1)
Article (Published version)

Secondary files (3)
Identifiers
- PID : unige:168526
- DOI : 10.1038/s41586-021-03862-z
- PMID : 34471285
Commercial URLhttps://www.nature.com/articles/s41586-021-03862-z
ISSN of the journal0028-0836