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Scientific article
English

High-Resolution Complementary Spatial Modulation of Magnetization (CSPAMM) Rat Heart Tagging on a 1.5 Tesla Clinical Magnetic Resonance System: A Preliminary Feasibility Study

Published inInvestigative radiology, vol. 42, no. 3, p. 204-210
Publication date2007-03
Abstract

The purpose of this study was to assess the feasibility of cardiac magnetic resonance (MR) tagging in rats on a standard clinical 1.5T MR system. Small animal models have been largely used as an experimental model in cardiovascular disease studies but mainly on high field systems (>4T) dedicated to research. Given the larger availability of routine clinical MR systems in centers with active cardiac research programs, it is of great interest to perform small animal imaging on whole-body MR systems of moderate field strength. The feasibility study was performed on 7 rats within 6 to 8 hours after myocardial infarction and 3 normal control rats. Myocardial strain was measured successfully in normal rats using the harmonic phase (ie, HARP) method, and a transmural gradient was demonstrated. In a rat model of acute occlusion/reperfusion, the myocardial circumferential strains were decreased, but the transmural strain gradient was preserved. This study demonstrated the feasibility of cardiac MR tagging in rats with a subendocardial resolution using a clinical 1.5T system.

eng
Keywords
  • Animals
  • Feasibility Studies
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging / instrumentation
  • Magnetic Resonance Imaging, Cine / instrumentation
  • Magnetic Resonance Imaging, Cine / methods
  • Myocardial Infarction / diagnosis
  • Myocardial Infarction / pathology
  • Myocardium / pathology
  • Phantoms, Imaging
  • Rats
  • Rats, Sprague-Dawley
Citation (ISO format)
IVANCEVIC, Marko Kresimir et al. High-Resolution Complementary Spatial Modulation of Magnetization (CSPAMM) Rat Heart Tagging on a 1.5 Tesla Clinical Magnetic Resonance System: A Preliminary Feasibility Study. In: Investigative radiology, 2007, vol. 42, n° 3, p. 204–210. doi: 10.1097/01.rli.0000255646.58831.4b
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ISSN of the journal0020-9996
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