en
Scientific article
English

Type D personality is associated with depressive symptoms and clinical activity in inflammatory bowel disease

Published inAlimentary pharmacology & therapeutics, vol. 54, no. 1, p. 53-67
Publication date2021-07
First online date2021-05-11
Abstract

Background: Inflammatory bowel disease (IBD) can be exacerbated by stress and depression. Type D personality, characterised by high negative affectivity and social inhibition, represents a vulnerability towards stressors and is associated with adverse outcomes in coronary heart disease.

Aims: To assess the prevalence of Type D personality in IBD patients and investigate potential associations with disease course.

Methods: We tested for associations between Type D (Type D Scale-14), depressive symptoms (Hospital Anxiety and Depression Scale's depression subscore ≥11) and recurrent IBD amongst Swiss IBD cohort patients. We built regression models for cross-sectional and Cox proportional hazards models for time-to-event analyses. IBD disease course was assessed by the future occurrence of active disease (Crohn's Disease Activity Index ≥150/Modified Truelove & Witts activity index ≥10) and several IBD-relevant endpoints.

Results: Amongst 2275 patients (1005 ulcerative colitis, 1270 Crohn's disease), 672 (29.5%) had Type D. Type D was a significant risk factor for future active disease (adjusted hazard ratio, aHR: 1.60, corrected P value, q = 0.007) and predicted the future presence of depressive symptoms (aHR: 3.30, P < 0.001). The combination of Type D and depressive symptoms further increased the risk for active disease (aHR: 3.98, q < 0.001). However, Type D associated depressive symptoms seemed to be the main contributor to this effect as Type D's predictive power decreased considerably in models corrected for depressive symptoms (aHR: 1.32, CI: 0.97-1.79, q = 0.292).

Conclusions: Type D personality's prevalence amongst IBD patients was comparable with its prevalence in the general population. Type D was strongly associated with depressive symptoms and showed modest independent associations with IBD prognosis.

eng
Keywords
  • Anxiety / epidemiology
  • Anxiety / etiology
  • Colitis, Ulcerative
  • Cross-Sectional Studies
  • Depression / epidemiology
  • Depression / etiology
  • Humans
  • Inflammatory Bowel Diseases / complications
  • Inflammatory Bowel Diseases / epidemiology
  • Type D Personality
Citation (ISO format)
JORDI, Sebastian Bruno Ulrich et al. Type D personality is associated with depressive symptoms and clinical activity in inflammatory bowel disease. In: Alimentary pharmacology & therapeutics, 2021, vol. 54, n° 1, p. 53–67. doi: 10.1111/apt.16365
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Identifiers
ISSN of the journal0269-2813
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