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Scientific article
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English

Toxoplasma gondii HOOK-FTS-HIP Complex is Critical for Secretory Organelle Discharge during Motility, Invasion, and Egress

Published inMBio, e00458-23
Publication date2023-04-24
First online date2023-04-24
Abstract

Toxoplasma gondii affects between 30 and 80% of the human population, poses a life-threatening risk to immunocompromised individuals, and is a cause of abortion and birth defects following congenital transmission. T. gondii belongs to the phylum of Apicomplexa characterized by a set of unique apical secretory organelles called the micronemes and rhoptries. Upon host cell recognition, this obligatory intracellular parasite secretes specific effectors contained in micronemes and rhoptries to promote parasite invasion of host cells and subsequent persistence.

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Funding
  • European Commission - Molecular Basis of Toxoplasma gondii Encystation and Persistence [695596]
  • European Commission - Molecular Basis of Toxoplasma gondii Encystation and Persistence [695596]
Citation (ISO format)
DUBOIS, David Jean et al. Toxoplasma gondii HOOK-FTS-HIP Complex is Critical for Secretory Organelle Discharge during Motility, Invasion, and Egress. In: MBio, 2023, p. e00458–23. doi: 10.1128/mbio.00458-23
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Article (Published version)
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ISSN of the journal2150-7511
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Technical informations

Creation04/24/2023 2:59:01 PM
First validation04/25/2023 7:38:05 AM
Update time04/25/2023 7:38:05 AM
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