Scientific article

Quantification of myocardial perfusion by MRI after coronary occlusion

Published inMagnetic resonance in medicine, vol. 40, no. 2, p. 287-297
Publication date1998-08

The objectives of this study were to define the relationship between the first order constant of Gd-DTPA transfer (K1) and the myocardial blood flow (MBF) at rest and to compare it with an equivalent relationship obtained for positron emission tomography (PET). In a canine model of permanent coronary occlusion (n = 4), myocardial and blood time concentration curves obtained by 13N-ammonia PET and Gd-DTPA-enhanced MRI were fitted by a one-compartment model to determine K1. A linear relationship was observed between MRIderived K1 and MBF measured by microspheres (K1 = 0.88 × flow −0.015, R = 0.95), which compares favorably with the equivalent relationship derived from PET (K1 = 0.74 × flow +0.16, R = 0.88). The results of this preliminary study suggest that, at rest and distal to a permanently occluded coronary artery, myocardial perfusion quantification by MRI is possible and can challenge PET.

  • Animals
  • Blood Flow Velocity / physiology
  • Contrast Media
  • Coronary Circulation / physiology
  • Dogs
  • Gadolinium DTPA
  • Image Enhancement
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging
  • Myocardial Infarction / diagnosis
  • Myocardium / pathology
  • Regional Blood Flow / physiology
  • Tomography, Emission-Computed
Affiliation Not a UNIGE publication
Citation (ISO format)
VALLÉE, Jean-Paul et al. Quantification of myocardial perfusion by MRI after coronary occlusion. In: Magnetic resonance in medicine, 1998, vol. 40, n° 2, p. 287–297. doi: 10.1002/mrm.1910400215
Main files (1)
Article (Published version)
ISSN of the journal0740-3194

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