Scientific article

Efficacy of lamotrigine in idiopathic generalized epilepsy syndromes: a video-EEG-controlled, open study

Published inEpileptic disorders, vol. 1, no. 3, p. 159-165
Publication date1999-09

Purpose: This prospective, open, video-EEG-controlled study examined the efficacy of lamotrigine (LTG) as add-on and monotherapy in idiopathic generalized epilepsy (IGE).

Methods: 47 patients received LTG either because of insufficient seizure control (n = 35) or serious side effects of prior antiepileptic drugs (AED). Long-term video-EEG recordings were performed before and after the introduction of LTG. The mean follow-up time was 25.5 months.

Results: Of 12 patients with refractory childhood absence epilepsy, 9 became seizure free; in one child with absences with eyelid myoclonia, absence frequency was reduced > 50%; in 2 children with absences with a mild atonic component, seizure reduction was only transient. Of 12 patients with juvenile absence epilepsy, 10 became seizure-free and, in 2, a > 50% reduction was obtained. In 15 patients with juvenile myoclonic epilepsy, complete seizure control was achieved in 7 patients, in 6 patients myoclonia persisted. In one patient generalized tonic-clonic seizures also persisted and another patient developed a rash, LTG was therefore stopped. Of 5 patients with grand-mal on awakening, 3 became seizure-free, and a reduction of > 50% was obtained in one patient; LTG was stopped in one patient because of poor compliance. Three patients with pure photosensitive epilepsy became seizure-free. At the end of the study, 11 patients were seizure-free on LTG monotherapy, and in most other patients concomitant AED dosage could be substantially reduced.

Conclusions: Lamotrigine was effective and well tolerated in patients with various IGE syndromes, although differences were observed between individual syndromes and seizure types.

  • Adolescent
  • Adult
  • Anticonvulsants / administration & dosage
  • Anticonvulsants / adverse effects
  • Child
  • Child, Preschool
  • Dose-Response Relationship, Drug
  • Drug Therapy, Combination
  • Electroencephalography / drug effects
  • Epilepsies, Myoclonic / diagnosis
  • Epilepsies, Myoclonic / drug therapy
  • Epilepsy, Absence / diagnosis
  • Epilepsy, Absence / drug therapy
  • Epilepsy, Generalized / diagnosis
  • Epilepsy, Generalized / drug therapy
  • Female
  • Follow-Up Studies
  • Humans
  • Lamotrigine
  • Male
  • Middle Aged
  • Prospective Studies
  • Treatment Outcome
  • Triazines / administration & dosage
  • Triazines / adverse effects
  • Video Recording
Citation (ISO format)
GERICKE, Christian A et al. Efficacy of lamotrigine in idiopathic generalized epilepsy syndromes: a video-EEG-controlled, open study. In: Epileptic disorders, 1999, vol. 1, n° 3, p. 159–165.
Main files (2)
Article (Published version) - version en ligne
Article (Published version) - version imprimée
ISSN of the journal1294-9361

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