The synthesis of an amine-bearing polymerizable phospholipid

Zaffalon, Pierre Léonard; Stalder, Etienne; Fedotenko, Illya; Favarger, France; Zumbuehl, Andréas

doi:10.1016/j.tetlet.2011.06.031

Scientific article

English

The synthesis of an amine-bearing polymerizable phospholipid

ContributorsZaffalon, Pierre Léonard; Stalder, Etienne; Fedotenko, Illya; Favarger, France; Zumbuehl, Andréas

Published inTetrahedron letters, vol. 52, no. 32, p. 4215-4217

Publication date2011

Abstract

Exchange of the natural glycerol phospholipid backbone with an artificial 1,3-diaminopropanol backbone led to the first synthetic 1,3-diaminophospholipid. The amines in the polar head group region were reacted to acrylamides giving a UV polymerizable phospholipid. Preliminary experiments demonstrate that formulated vesicles can be polymerized into large aggregates of vesicles.

Keywords

Artificial phospholipids
Phospholipid synthesis
Amine-bearing phospholipids
Polymerizable phospholipids
Polymeric vesicles

Affiliation entities

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

ZAFFALON, Pierre Léonard et al. The synthesis of an amine-bearing polymerizable phospholipid. In: Tetrahedron letters, 2011, vol. 52, n° 32, p. 4215–4217. doi: 10.1016/j.tetlet.2011.06.031

Article (Published version)

Identifiers

PID : unige:16742
DOI : 10.1016/j.tetlet.2011.06.031

Additional URL for this publicationhttp://linkinghub.elsevier.com/retrieve/pii/S0040403911009713

Journal ISSN0040-4039

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The synthesis of an amine-bearing polymerizable phospholipid

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