Scientific article
OA Policy
English

The effects of time‐restricted eating and weight loss on bone metabolism and health: a 6‐month randomized controlled trial

Published inObesity, vol. 31, no. S1, no. Time-Restricted Eating: Update on Latest Developments, p. 85-85
Publication date2023-02
First online date2022-10-14
Abstract

Objective: This study explored the impact of time-restricted eating (TRE) versus standard dietary advice (SDA) on bone health.

Methods: Adults with ≥1 component of metabolic syndrome were randomized to TRE (ad libitum eating within 12 hours) or SDA (food pyramid brochure). Bone turnover markers and bone mineral content/density by dual energy x-ray absorptiometry were assessed at baseline and 6-month follow-up. Statistical analyses were performed in the total population and by weight loss response.

Results: In the total population (n = 42, 76% women, median age 47 years [IQR: 31-52]), there were no between-group differences (TRE vs. SDA) in any bone parameter. Among weight loss responders (≥0.6 kg weight loss), the bone resorption marker β-carboxyterminal telopeptide of type I collagen tended to decrease after TRE but increase after SDA (between-group differences p = 0.041), whereas changes in the bone formation marker procollagen type I N-propeptide did not differ between groups. Total body bone mineral content decreased after SDA (p = 0.028) but remained unchanged after TRE (p = 0.31) in weight loss responders (between-group differences p = 0.028). Among nonresponders (<0.6 kg weight loss), there were no between-group differences in bone outcomes.

Conclusions: TRE had no detrimental impact on bone health, whereas, when weight loss occurred, it was associated with some bone-sparing effects compared with SDA.

Keywords
  • Absorptiometry, Photon
  • Adult
  • Bone Density / physiology
  • Bone and Bones
  • Female
  • Humans
  • Male
  • Middle Aged
  • Weight Loss
Citation (ISO format)
PAPAGEORGIOU, Maria et al. The effects of time‐restricted eating and weight loss on bone metabolism and health: a 6‐month randomized controlled trial. In: Obesity, 2023, vol. 31, n° S1, p. 85–85. doi: 10.1002/oby.23577
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Article (Published version)
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Identifiers
ISSN of the journal1930-7381
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Technical informations

Creation10/27/2022 1:01:00 PM
First validation10/27/2022 1:01:00 PM
Update time03/16/2023 10:55:10 AM
Status update03/16/2023 10:55:09 AM
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