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Scientific article
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Synthesis and characterization of self-catalyzed poly(ortho-esters) based on decanediol and decanediol-lactate

Published inJournal of biomaterials science. Polymer ed, vol. 10, no. 3, p. 375-389
Publication date1999
Abstract

The synthesis of poly(ortho-esters) (POEs) containing lactic acid dimers in the polymer backbone for possible use in controlled drug release applications is described. These autocatalyzed POEs are prepared by the acid catalyzed condensation of 3,9-diethylidene-2,4,8,10-tetraoxaspiro(5,5)undecane with diols to produce linear polymers. The diols used were a mixture of decanediol-lactate and decanediol in various molar ratio to produce polymers with different lactic acid contents. Polymer structures were confirmed by 13C NMR, 1H NMR, and FT-IR and physio-chemical properties, such as molecular weights, glass transition temperatures and viscoleastic behavior, were also determined.

eng
Keywords
  • Poly(ortho-esters)
  • Bioerodible polymers
  • Polymer synthesis
  • Polymer characterization
  • Autocatalyzed polymer
Citation (ISO format)
SCHWACH, Khadija, HELLER, Jorge, GURNY, Robert. Synthesis and characterization of self-catalyzed poly(ortho-esters) based on decanediol and decanediol-lactate. In: Journal of biomaterials science. Polymer ed, 1999, vol. 10, n° 3, p. 375–389. doi: 10.1163/156856299X00432
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ISSN of the journal0920-5063
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