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Scientific article
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French

Traitement hormonal substitutif de l’hypoparathyroïdie : quels bénéfices ?

Other titlePTH-replacement therapy in hypoparathyroidism : what benefits ?
Published inRevue médicale suisse, vol. 17, no. 735, p. 788-792
Publication date2021-04-21
Abstract

Hypoparathyroidism is a rare disease. In the last decade, important publications have described clinical disease progression and long-term complications. Furthermore, this condition has benefited from major therapeutic advances with the emergence of a hormonal substitution therapy with injectable parathyroid hormone, rhPTH (1-84) (Recombinant human parathyroid hormone, 1-84). Conventional therapy, with calcium supplements and active vitamin D analogue, is effective but does not always fulfill all therapeutic targets and is associated with hypercalciuria. In most patients, therapy with rhPTH (1-84) is associated with a substantial reduction of at least 50% in the need for calcium and active vitamin D along with maintenance of serum calcium. Additionally, rhPTH (1-84) is associated with decreased in 24h urinary calcium excretion with preservation of renal function, which can be a major asset.

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Keywords
  • Calcium
  • Hormone Replacement Therapy
  • Humans
  • Hypoparathyroidism / drug therapy
  • Parathyroid Hormone / therapeutic use
  • Recombinant Proteins
  • Vitamin D / therapeutic use
Citation (ISO format)
TROMBETTI, Andrea, BÉGIN, Marie-Josée. Traitement hormonal substitutif de l’hypoparathyroïdie : quels bénéfices ? In: Revue médicale suisse, 2021, vol. 17, n° 735, p. 788–792. doi: 10.53738/REVMED.2021.17.735.0788
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Article (Published version)
accessLevelPublic
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ISSN of the journal1660-9379
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