Scientific article
Open access

Biofilms and Cyclic di-GMP (c-di-GMP) Signaling: Lessons from Pseudomonas aeruginosa and Other Bacteria

Published inJournal of biological chemistry, vol. 291, no. 24, p. 12547-12555
Publication date2016-06-10
First online date2016-04-21

The cyclic di-GMP (c-di-GMP) second messenger represents a signaling system that regulates many bacterial behaviors and is of key importance for driving the lifestyle switch between motile loner cells and biofilm formers. This review provides an up-to-date compendium of c-di-GMP pathways connected to biofilm formation, biofilm-associated motilities, and other functionalities in the ubiquitous and opportunistic human pathogen Pseudomonas aeruginosa This bacterium is frequently adopted as a model organism to study bacterial biofilm formation. Importantly, its versatility and adaptation capabilities are linked with a broad range of complex regulatory networks, including a large set of genes involved in c-di-GMP biosynthesis, degradation, and transmission.

  • Pseudomonas aeruginosa (P. aeruginosa)
  • Antibiotic resistance
  • Biofilm
  • Cyclic di-GMP (c-di-GMP)
  • Signaling
  • Bacteria / genetics
  • Bacteria / metabolism
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Biofilms / growth & development
  • Biosynthetic Pathways / genetics
  • Cyclic GMP / analogs & derivatives
  • Cyclic GMP / metabolism
  • Humans
  • Models, Biological
  • Pseudomonas aeruginosa / genetics
  • Pseudomonas aeruginosa / metabolism
  • Pseudomonas aeruginosa / physiology
  • Second Messenger Systems / physiology
  • Signal Transduction / physiology
Affiliation Not a UNIGE publication
Citation (ISO format)
VALENTINI, Martina, FILLOUX, Alain. Biofilms and Cyclic di-GMP (c-di-GMP) Signaling: Lessons from Pseudomonas aeruginosa and Other Bacteria. In: Journal of biological chemistry, 2016, vol. 291, n° 24, p. 12547–12555. doi: 10.1074/jbc.R115.711507
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Article (Published version)
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ISSN of the journal0021-9258

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