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The role of natural killer cells in the immune response against CMV infection in immunosuppressed patients

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Defense Thèse de doctorat : Univ. Genève, 2011 - Sc. 4321 - 2011/04/08
Abstract Natural Killer (NK) cells are part of the innate immune system and represent 5 to 15% of the total lymphocytes in a healthy individual. At their surface different families of inhibitory and activating receptors are expressed, where the killer immunoglobulin-like receptors (KIR) are of special interest. NK cells reactivity will depend on the binding of their receptors and their specific ligands, the major histocompatibility complex I (MHC-I). This KIR-MHC-I interaction plays an important role in transplantation. As transplanted patients are immunosuppressed, they represent an easy target to opportunistic infections, such as cytomegalovirus (CMV). Specific T-cells can clear CMV infection, but immunosuppressive drugs, which help to tolerate the graft, inhibit the activity of these T-cells. Interestingly, NK cells seem not affected by these drugs. The aim of this thesis is to investigate the anti-viral role of the NK cells during CMV infection after solid organ transplantation.
Keywords NK cellsKIR ReceptorsCMVTransplantation
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URN: urn:nbn:ch:unige-166973
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DE RHAM, Casimir. The role of natural killer cells in the immune response against CMV infection in immunosuppressed patients. Université de Genève. Thèse, 2011. https://archive-ouverte.unige.ch/unige:16697

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Deposited on : 2011-07-27

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