Statement of problem: Three-dimensional printing has facilitated the fabrication processes in dentistry. However, knowledge on the effect of layer thickness on the trueness of 3D-printed fixed partial dentures (FPDs) is lacking.

Purpose: The purpose of this in vitro study was to compare the effect of printing layer thickness on the trueness of 3-unit interim FPDs fabricated by using additive manufacturing with that of those fabricated by subtractive manufacturing.

Material and methods: The right first premolar and first molar teeth of a dentate mandibular model were prepared for a 3-unit restoration and then digitized by using an intraoral scanner. A 3-unit interim FPD was designed to fabricate 40 restorations by using either the additive (NextDent C&B MFH) with layer thicknesses of 20 μm (n=10), 50 μm (n=10), and 100 μm (n=10) or subtractive manufacturing technique (Upcera) (milled, n=10). After fabrication, the interim FPDs were digitized by using the same intraoral scanner and were superimposed over the design data by using a 3D analysis software program. Root mean square (RMS) was used to analyze the trueness of the restorations at 4 different surfaces (external, intaglio, marginal area, and intaglio occlusal) and as a complete unit (overall). Data were analyzed with the Kruskal-Wallis and Wilcoxon tests with Bonferroni correction (α=.05).

Results: The 100-μm-layer thickness interim FPDs showed the greatest overall (P≤.015), external (P≤.021), and intaglio occlusal (P≤.021) deviations, whereas the milled interim FPDs showed the lowest (P=.001). No significant differences were found among the test groups for marginal RMS (P≥.108). The differences between the 50-μm-layer thickness and 100-μm-layer thickness interim FPDs for the intaglio surface deviations (P=.064) and between the 20-μm-layer thickness and 50-μm-layer thickness interim FPDs for each surface tested were not statistically significant (P≥.108).

Conclusions: The printing layer thickness had a significant effect on the trueness of the additively manufactured interim FPDs. However, subtractively manufactured interim FPDs presented higher trueness than those additively manufactured, regardless of the printing layer thickness.