No Plasmatic Proteomic Signature at Clinical Disease Onset Associated With 11 Year Clinical, Cognitive and MRI Outcomes in Relapsing-Remitting Multiple Sclerosis Patients

Bridel, Claire; Eijlers, Anand J C; van Wieringen, Wessel N; Koel-Simmelink, Marleen; Leurs, Cyra E; Schoonheim, Menno M; Killestein, Joep; Teunissen, Charlotte E

doi:10.3389/fnmol.2018.00371

Article scientifique

Accès libre

Anglais

No Plasmatic Proteomic Signature at Clinical Disease Onset Associated With 11 Year Clinical, Cognitive and MRI Outcomes in Relapsing-Remitting Multiple Sclerosis Patients

Contributeurs/tricesBridel, Claire

; Eijlers, Anand J C; van Wieringen, Wessel N

; Koel-Simmelink, Marleen; Leurs, Cyra E; Schoonheim, Menno M

; Killestein, Joep

; Teunissen, Charlotte E

Publié dansFrontiers in molecular neuroscience, vol. 11, 371

Date de publication2018-10-31

Date de mise en ligne2018-10-31

Résumé

Background: The clinical course of relapsing-remitting multiple sclerosis (RRMS) is highly heterogeneous and prognostic biomarkers at time of diagnosis are lacking.

Objective: We investigated the predictive value of the plasma proteome at time of diagnosis in RRMS patients.

Methods: The plasma proteome was interrogated using a novel aptamer-based proteomics platform, which allows to measure the levels of a predefined set of 1310 proteins.

Results: In 67 clinically and radiologically well characterized RRMS patients, we found no association between the plasma proteome at diagnosis and clinical, cognitive or MRI outcomes after 11 years.

Conclusions: Proteomics studies on cerebrospinal fluid may be better suited to identify prognostic biomarkers in early RRMS.

Mots-clés

MRI
Cognition
Multiple sclerosis
Prognosis
Proteomics

Structure d'affiliation Pas une publication de l'UNIGE

Citation (format ISO)

BRIDEL, Claire et al. No Plasmatic Proteomic Signature at Clinical Disease Onset Associated With 11 Year Clinical, Cognitive and MRI Outcomes in Relapsing-Remitting Multiple Sclerosis Patients. In: Frontiers in molecular neuroscience, 2018, vol. 11, p. 371. doi: 10.3389/fnmol.2018.00371