No Plasmatic Proteomic Signature at Clinical Disease Onset Associated With 11 Year Clinical, Cognitive and MRI Outcomes in Relapsing-Remitting Multiple Sclerosis Patients

Bridel, Claire; Eijlers, Anand J C; van Wieringen, Wessel N; Koel-Simmelink, Marleen; Leurs, Cyra E; Schoonheim, Menno M; Killestein, Joep; Teunissen, Charlotte E

doi:10.3389/fnmol.2018.00371

Scientific article

English

No Plasmatic Proteomic Signature at Clinical Disease Onset Associated With 11 Year Clinical, Cognitive and MRI Outcomes in Relapsing-Remitting Multiple Sclerosis Patients

ContributorsBridel, Claire

; Eijlers, Anand J C; van Wieringen, Wessel N

; Koel-Simmelink, Marleen; Leurs, Cyra E; Schoonheim, Menno M

; Killestein, Joep

; Teunissen, Charlotte E

Published inFrontiers in molecular neuroscience, vol. 11, 371

Publication date2018-10-31

First online date2018-10-31

Abstract

Background: The clinical course of relapsing-remitting multiple sclerosis (RRMS) is highly heterogeneous and prognostic biomarkers at time of diagnosis are lacking.

Objective: We investigated the predictive value of the plasma proteome at time of diagnosis in RRMS patients.

Methods: The plasma proteome was interrogated using a novel aptamer-based proteomics platform, which allows to measure the levels of a predefined set of 1310 proteins.

Results: In 67 clinically and radiologically well characterized RRMS patients, we found no association between the plasma proteome at diagnosis and clinical, cognitive or MRI outcomes after 11 years.

Conclusions: Proteomics studies on cerebrospinal fluid may be better suited to identify prognostic biomarkers in early RRMS.

Keywords

MRI
Cognition
Multiple sclerosis
Prognosis
Proteomics

Affiliation entities

Not a UNIGE publication

Citation (ISO format)

BRIDEL, Claire et al. No Plasmatic Proteomic Signature at Clinical Disease Onset Associated With 11 Year Clinical, Cognitive and MRI Outcomes in Relapsing-Remitting Multiple Sclerosis Patients. In: Frontiers in molecular neuroscience, 2018, vol. 11, p. 371. doi: 10.3389/fnmol.2018.00371