Scientific article
Open access

Variations in consecutive serum neurofilament light levels in healthy controls and multiple sclerosis patients

Published inMultiple sclerosis and related disorders, vol. 47, 102666
Publication date2021-01
First online date2020-12-01

Background Neurofilament light is a neuronal protein detectable in serum (sNfL), with high potential as disease activity biomarker in multiple sclerosis (MS). To date, little is known about sNfL fluctuations between 2 consecutive measurements in healthy controls (HC) and MS patients. Yet this information is critical, as it will help define a clinically significant variation. Methods sNfL was measured at 2 consecutive time points in a cohort of 90 MS patients (untreated relapsing remitting MS (uRRMS), n=35; treated relapsing remitting MS (tRRMS), n= 21; secondary progressive MS, SPMS, n=21; primary progressive MS, PPMS, n=13), and 90 age-matched HC, using the Simoa NfL light® assay. Results Mean sNfL was elevated in all MS subtypes compared to HC (p<0.0001), and positively associated with age in HC (r=0.70, p<0.001), confirming previous reports. Mean sNfL was higher at follow-up compared to baseline in HC (p<0.001), and lower in uRRMS(p=0.036) and tRRMS (p=0.008). At follow-up, a similar proportion of HC (50.0%), untreated RRMS (51.4%), treated RRMS (33.3%), SPMS (45.0%) and PPMS (46.2%) had variations in sNfL levels exceeding 20% of baseline levels. Conclusions Our data suggest variations in sNfL occur both in HC and MS populations to a similar extent and magnitude. Variations between two consecutive sNfL measurements may reflect natural variations and not necessarily variations in inflammatory disease activity.

  • Biomarkers
  • Humans
  • Intermediate Filaments
  • Multiple Sclerosis
  • Multiple Sclerosis, Relapsing-Remitting / diagnostic imaging
  • Neurofilament Proteins
Citation (ISO format)
BRIDEL, Claire et al. Variations in consecutive serum neurofilament light levels in healthy controls and multiple sclerosis patients. In: Multiple sclerosis and related disorders, 2021, vol. 47, p. 102666. doi: 10.1016/j.msard.2020.102666
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ISSN of the journal2211-0348

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