en
Scientific article
Open access
English

Dengue fever in Dar es Salaam, Tanzania: clinical features and outcome in populations of black and non-black racial category

Published inBMC infectious diseases, vol. 18, no. 1, 644
Publication date2018-12-12
First online date2018-12-12
Abstract

Background: Although the incidence of dengue across Africa is high, severe dengue is reported infrequently. We describe the clinical features and the outcome of dengue according to raceduring an outbreak in Dar es Salaam, Tanzania that occurred in both native and expatriate populations.

Methods: Adults with confirmed dengue (NS1 and/or IgM on rapid diagnostic test and/or PCR positive) were included between December 2013 and July 2014 in outpatient clinics. Seven-day outcome was assessed by a visit or a call. Association between black race and clinical presentation, including warning signs, was assessed by logistic regression adjusted for age, malaria coinfection, secondary dengue and duration of symptoms at inclusion. The independent association between demographic and comorbidities characteristics of the patients and severe dengue was evaluated by multivariate logistic regression that included potential confounders.

Results: After exclusion of 3 patients of mixed race, 431 patients with dengue (serotype 2, genotype Cosmopolitan) were included: 241 of black and 190 of non-black race. Black patients were younger (median age 30 versus 41 years; p < 0.001) and attended care after a slightly longer duration of symptoms (median of 2.9 versus 2.7 days; p = 0.01). Malaria coinfection was not significantly different between black (5%) and non-black (1.6%) patients (p = 0.06). The same proportion of patients in both group had secondary dengue (13 and 14%; p = 0.78). Among warning signs, only mucosal bleed was associated with race, black race being protective (adjusted OR 0.44; 95% CI 0.21-0.92). Overall, 20 patients (4.7%) presented with severe dengue. Non-black race (adjusted OR 3.9; 95% CI 1.3-12) and previously known diabetes (adjusted OR 43; 95% CI 5.2-361) were independently associated with severe dengue.

Conclusions: Although all patients were infected with the same dengue virus genotype, black race was independently protective against a severe course of dengue, suggesting the presence of protective genetic or environmental host factors among people of African ancestry. The milder clinical presentation of dengue in black patients might partly explain why dengue outbreaks are under-reported in Africa and often mistaken for malaria. These results highlight the need to introduce point-of-care tests, beside the one for malaria, to detect outbreaks and orientate diagnosis.

Trial registration: Clinicaltrials.gov Identifier: NCT01947075 , retrospectively registered on the 13 of September 2014.

eng
Keywords
  • Dengue
  • Outbreak
  • Race
  • Sub-saharan Africa
  • Surveillance
  • Adult
  • Blacks / statistics & numerical data
  • Coinfection / epidemiology
  • Dengue Virus / genetics
  • Dengue Virus / isolation & purification
  • Disease Outbreaks
  • Ethnicity / statistics & numerical data
  • Female
  • Humans
  • Incidence
  • Malaria / diagnosis
  • Malaria / epidemiology
  • Malaria / ethnology
  • Male
  • Middle Aged
  • Prognosis
  • Retrospective Studies
  • Serogroup
  • Severe Dengue / diagnosis
  • Severe Dengue / epidemiology
  • Severe Dengue / ethnology
  • Tanzania / epidemiology
  • Young Adult
Funding
  • Bill and Melinda Gates Foundation -
Citation (ISO format)
BOILLAT-BLANCO, Noémie et al. Dengue fever in Dar es Salaam, Tanzania: clinical features and outcome in populations of black and non-black racial category. In: BMC infectious diseases, 2018, vol. 18, n° 1, p. 644. doi: 10.1186/s12879-018-3549-z
Main files (1)
Article (Published version)
Secondary files (1)
Identifiers
ISSN of the journal1471-2334
50views
12downloads

Technical informations

Creation10/11/2022 11:21:00 AM
First validation10/11/2022 11:21:00 AM
Update time03/16/2023 10:33:50 AM
Status update03/16/2023 10:33:49 AM
Last indexation08/31/2023 10:32:50 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack