Scientific article
Open access

Hypothyroidism-Associated Dyslipidemia: Potential Molecular Mechanisms Leading to NAFLD

Published inInternational journal of molecular sciences, vol. 22, no. 23, 12797
Publication date2021-11-26
First online date2021-11-26

Thyroid hormones control lipid metabolism by exhibiting specific effects on the liver and adipose tissue in a coordinated manner. Different diseases of the thyroid gland can result in hypothyroidism. Hypothyroidism is frequently associated with dyslipidemia. Hypothyroidism-associated dyslipidemia subsequently results in intrahepatic accumulation of fat, leading to nonalcoholic fatty liver disease (NAFLD), which leads to the development of hepatic insulin resistance. The prevalence of NAFLD in the western world is increasing, and evidence of its association with hypothyroidism is accumulating. Since hypothyroidism has been identified as a modifiable risk factor of NAFLD and recent data provides evidence that selective thyroid hormone receptor β (THR-β) agonists are effective in the treatment of dyslipidemia and NAFLD, interest in potential therapeutic options for NAFLD targeting these receptors is growing. In this review, we summarize current knowledge regarding clinical and molecular data exploring the association of hypothyroidism, dyslipidemia and NAFLD.

  • Hypothyroidism
  • Insulin resistance
  • Animals
  • Dyslipidemias / etiology
  • Dyslipidemias / pathology
  • Humans
  • Hypothyroidism / complications
  • Insulin Resistance
  • Lipid Metabolism
  • Non-alcoholic Fatty Liver Disease / etiology
  • Non-alcoholic Fatty Liver Disease / pathology
  • Risk Factors
Citation (ISO format)
MAVROMATI, Maria, JORNAYVAZ, François. Hypothyroidism-Associated Dyslipidemia: Potential Molecular Mechanisms Leading to NAFLD. In: International journal of molecular sciences, 2021, vol. 22, n° 23, p. 12797. doi: 10.3390/ijms222312797
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Article (Published version)
ISSN of the journal1422-0067

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