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Scientific article
Open access
English

Regulator of oligodendrocyte maturation, miR-219, a potential biomarker for MS

Published inJournal of neuroinflammation, vol. 14, no. 1, 235
Publication date2017-12-04
First online date2017-12-04
Abstract

Background: Multiple sclerosis (MS) is a demyelinating and degenerative disease of the central nervous system. Normally, demyelination is followed by remyelination, which requires repopulation of a demyelinated area by oligodendrocyte precursor cells. Although large numbers of precursor cells are present in MS lesions, remyelination often fails, in part by the inability of precursor cells to differentiate into mature myelin-forming cells. In mouse and rat, miR-219 is required for this differentiation. Previously, we identified decreased miR-219 expression in tissue of MS patients compared to controls. Cell-free miRNAs have been detected in many different body fluids including cerebrospinal fluid (CSF) and may reflect disease processes going on in the central nervous system. This prompted us to investigate the biomarker performance of CSF miR-219 for MS diagnosis.

Methods: Quantitative PCR was performed measuring miR-219 levels in CSF of MS patients and controls in three independent cohorts.

Results: All three cohorts of MS patients and controls revealed that absence of miR-219 detection in CSF is consistently associated with MS.

Conclusions: We have been able to identify and validate absence of miR-219 detection in CSF of MS patients compared to controls, suggesting that it may emerge as a candidate biomarker for MS diagnosis.

eng
Keywords
  • Biomarkers
  • Cerebrospinal fluid
  • Multiple sclerosis
  • MiR-150
  • MiR-219
  • MiRNA
  • Adult
  • Biomarkers / cerebrospinal fluid
  • Female
  • Humans
  • Male
  • MicroRNAs / cerebrospinal fluid
  • Middle Aged
  • Multiple Sclerosis / cerebrospinal fluid
Affiliation Not a UNIGE publication
Funding
  • Schweizerische Multiple Sklerose Gesellschaft -
  • Stichting MS Research (NL) - [07-610 MS]
Citation (ISO format)
BRUINSMA, Ilona B et al. Regulator of oligodendrocyte maturation, miR-219, a potential biomarker for MS. In: Journal of neuroinflammation, 2017, vol. 14, n° 1, p. 235. doi: 10.1186/s12974-017-1006-3
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Article (Published version)
Identifiers
ISSN of the journal1742-2094
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