Scientific article
English

SINDy for delay-differential equations: application to model bacterial zinc response

Publication date2023-01-04
First online date2023-01-04
Abstract

We extend the data-driven method of sparse identification of nonlinear dynamics (SINDy) developed by Brunton et al. , Proc. Natl Acad. Sci. USA 113 (2016) to the case of delay differential equations (DDEs). This is achieved in a bilevel optimization procedure by first applying SINDy for fixed delay and then subsequently optimizing the error of the reconstructed SINDy model over delay times. We test the SINDy-delay method on a noisy short dataset from a toy DDE and show excellent agreement. We then apply the method to experimental data of gene expressions in the bacterium Pseudomonas aeruginosa subject to the influence of zinc. The derived SINDy model suggests that the increase in zinc concentration mainly affects the time delay and not the strengths of the interactions between the different agents controlling the zinc export mechanism.

Keywords
  • Data-driven modelling
  • SINDy
  • Delay-differential equations
  • Pseudomonas aeruginosa
  • Zinc homeostasis
Research groups
Citation (ISO format)
SANDOZ, Antoine et al. SINDy for delay-differential equations: application to model bacterial zinc response. In: Proceedings - Royal Society. Mathematical, physical and engineering sciences, 2023, vol. 479, n° 2269, p. 20220556. doi: 10.1098/rspa.2022.0556
Main files (2)
Article (Submitted version)
Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN1364-5021
276views
420downloads

Technical informations

Creation09/01/2023 11:14:00
First validation09/01/2023 11:14:00
Update16/03/2023 10:24:27
Status update16/03/2023 10:24:26
Last indexation01/11/2024 03:52:27
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack