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Scientific article
Open access
English

Association Between Immunogenicity and Reactogenicity: A Post Hoc Analysis of 2 Phase 3 Studies With the Adjuvanted Recombinant Zoster Vaccine

Published inThe journal of infectious diseases, vol. 226, no. 11, p. 1943-1948
Publication date2022-11-28
Abstract

A recurrent question is whether transient reactions to vaccines translate into better immune responses. Using clinical data from 2 large phase 3 studies of the recombinant zoster vaccine, we observed a small but statistically significant association between the intensity of a frequent side effect (pain) after vaccination and immune responses to vaccination. However, despite the statistical correlation, the impact on the immune response is so small, and the immune response in individuals without pain already sufficient, that pain cannot be a surrogate marker for an appropriate immune response. Reactogenicity cannot be used to predict immunity after vaccination.

eng
Keywords
  • AS01
  • T cells
  • Antibodies
  • Reactogenicity
  • Recombinant zoster vaccine
  • Humans
  • Adjuvants, Immunologic / adverse effects
  • Adjuvants, Pharmaceutic
  • Herpes Zoster / prevention & control
  • Herpes Zoster Vaccine / adverse effects
  • Immunogenicity, Vaccine
  • Pain / chemically induced
  • Vaccines, Synthetic / adverse effects
Affiliation Not a UNIGE publication
Citation (ISO format)
CALLEGARO, Andrea et al. Association Between Immunogenicity and Reactogenicity: A Post Hoc Analysis of 2 Phase 3 Studies With the Adjuvanted Recombinant Zoster Vaccine. In: The journal of infectious diseases, 2022, vol. 226, n° 11, p. 1943–1948. doi: 10.1093/infdis/jiab536
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Article (Published version)
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Identifiers
ISSN of the journal0022-1899
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