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Scientific article
English

Ni-Catalyzed Enantioselective Hydrofunctionalizations of 1,3-Dienes

Published inACS Catalysis, vol. 12, no. 24, p. 15638-15647
Publication date2022-12-16
First online date2022-12-06
Abstract

Ni-catalyzed enantioselective hydrofunctionalizations of conjugated dienes are particularly demanding reactions to devise because they require not only addressing the inherent challenges associated with the development of an enantioselective transformation but also overcoming all other aspects of selective catalysis (chemoselectivity, regioselectivity, diastereoselectivity, etc.). However, the value-added nature of the chiral allylic and homoallylic derivatives obtained by these methods, the lack of efficient alternatives, and the use of an earth-abundant first-row transition metal have led to renewed interest over the past decade. In this Perspective, we give an overview of the developments in this field, from the original findings (often dating back to the last century) to the most recent contributions. Emphasis is placed on the nature of the hydrofunctionalization agent (C(sp), C(sp2), C(sp3), N, P, or O).

eng
Keywords
  • Amines
  • Ligands
  • Organic reactions
  • Selectivity
  • Stereoselectivity
Research group
Citation (ISO format)
FLAGET, Arthur, ZHANG, Cheng, MAZET, Clement. Ni-Catalyzed Enantioselective Hydrofunctionalizations of 1,3-Dienes. In: ACS Catalysis, 2022, vol. 12, n° 24, p. 15638–15647. doi: 10.1021/acscatal.2c05251
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ISSN of the journal2155-5435
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