Scientific article

Chitosan as Tear Substitute: A Wetting Agent Endowed with Antimicrobial Efficacy

Published inJournal of Ocular Pharmacology and Therapeutics, vol. 16, no. 3, p. 261-270
Publication date2000-06
First online date2009-01-30

A cationic biopolymer, chitosan, is proposed for use in artificial tear formulations. It is endowed with good wetting properties as well as an antibacterial effect that are desirable in cases of dry eye, which is often complicated by secondary infections. Solutions containing 0.5% w/v of a low molecular weight (Mw) chitosan (160 kDa) were assessed for antibacterial efficacy against E. coli and S. aureus by using the usual broth-dilution technique. The in vitro evaluation showed that concentrations of chitosan as low as 0.0375% still exert a bacteriostatic effect against E. coli. Minimal inhibitory concentration (MIC) values of chitosan were calculated to be as low as 0.375 mg/ml for E. coli and 0.15 mg/ml for S. aureus. Gamma scintigraphic studies demonstrated that chitosan formulations remain on the precorneal surface as long as commonly used commercial artificial tears (Protagent® collyrium and Protagent-SE® unit-dose) having a 5-fold higher viscosity.

Citation (ISO format)
FELT-BAEYENS, Olivia et al. Chitosan as Tear Substitute: A Wetting Agent Endowed with Antimicrobial Efficacy. In: Journal of Ocular Pharmacology and Therapeutics, 2000, vol. 16, n° 3, p. 261–270. doi: 10.1089/jop.2000.16.261
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Article (Published version)
ISSN of the journal1080-7683

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