Scientific article
Open access

Diaphragm dysfunction and peripheral muscle wasting in septic shock patients: Exploring their relationship over time using ultrasound technology (the MUSiShock protocol)

Published inPloS one, vol. 17, no. 3, e0266174
Publication date2022
First online date2022-03-28

Background: Intensive Care Unit (ICU) patients are known to lose muscle mass and function during ICU stay. Ultrasonography (US) application for the assessment of the skeletal muscle is a promising tool and might help detecting muscle changes and thus several dysfunctions during early stages of ICU stay. MUSiShock is a research project aiming to investigate structure and function of diaphragm and peripheral muscles using ultrasound techniques in septic shock patients, and to assess their relevance in several clinical outcomes such as the weaning process.

Methods and design: This is a research protocol from an observational prospective cohort study. We plan to assess eighty-four septic shock patients during their ICU stay at the following time-points: at 24 hours of ICU admission, then daily until day 5, then weekly, at extubation time and at ICU discharge. At each time-point, we will measure the quadriceps rectus femoris and diaphragm muscles, using innovative US muscle markers such as Shear-Wave Elastography (SWE). In parallel, the Medical Research Council (MRC) sum score for muscle testing and the Airway occlusion pressure (P0.1) will also be collected. We will describe the association between SWE assessment and other US markers for each muscle. The association between the changes in both diaphragm and rectus femoris US markers over time will be explored as well; finally, the analysis of a combined model of one diaphragm US marker and one limb muscle US marker to predict weaning success/failure will be tested.

Discussion: By using muscle ultrasound at both diaphragm and limb levels, MUSiShock aims to improve knowledge in the early detection of muscle dysfunction and weakness, and their relationship with muscle strength and MV weaning, in critically ill patients. A better anticipation of these short-term muscle structure and function outcomes may allow clinicians to rapidly implement measures to counteract it.

Trial registration: ClinicalTrials.gov, NCT04550143. Registered on 16 September 2020.

  • Critical Illness
  • Diaphragm / diagnostic imaging
  • Humans
  • Intensive Care Units
  • Muscle Weakness
  • Observational Studies as Topic
  • Prospective Studies
  • Shock, Septic / diagnostic imaging
  • Technology
  • Ultrasonography / methods
Citation (ISO format)
NETO DA VENDA E SILVA, Ivo Alexandre et al. Diaphragm dysfunction and peripheral muscle wasting in septic shock patients: Exploring their relationship over time using ultrasound technology (the MUSiShock protocol). In: PloS one, 2022, vol. 17, n° 3, p. e0266174. doi: 10.1371/journal.pone.0266174
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Article (Published version)
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ISSN of the journal1932-6203

Technical informations

Creation08/13/2022 9:22:00 AM
First validation08/13/2022 9:22:00 AM
Update time03/16/2023 10:16:01 AM
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